New Poly(Ionic Liquid) Based Fiber for Determination of Oxytetracycline in Milk Samples by Application of SPME-CE Technique
Abstract
:1. Introduction
2. Results and Discussion
2.1. Electropolymerization
2.2. Optimization of the SPME Procedure
2.3. Method Validation
2.4. The Environmental Impact of the Methodology
3. Experimental Section
3.1. Reagents and Chemicals
3.2. Equipment
3.3. Electropolymerization
3.4. Sample Preparation
3.5. Method Validation
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available from the authors. |
Parameter | Value | Parameter | Value |
---|---|---|---|
Concentration µg L−1 | 250 | Uncertainty | |
Calibration equation | Sample (usample) | 0.001 | |
Analytical sensitivity ± Sb1 | 0.691 ± 0.024 | Calibration (ucal) | 0.028 |
Intercept ± Sb0 | −0.028 ± 0.024 | Recovery (utrue) | 0.899 |
R2 | 0.9962 | Repeatability (urep) | 2.248 |
LOD µg L−1 | 70.36 | LOD (uLOD) | 0.280 |
Combined uncertainty | 0.98% | ||
RSD (n = 3) | 1.57 | Expanded uncertainty | 1.96% |
Result | |||
Concentration ± U(*k = 2) µg L−1 | 250 ± 4.9 |
Methodology | LOD (µg L−1) | %RSD (Intra day/Inter day) | Reference |
---|---|---|---|
HPLC-DAD | 50 | 2.3/4.1 | [6] |
SPE-HPLC-DAD | 113(µg kg−1) | 4.70 (inter day) | [29] |
SPE-HPLC-PDA | 1.5 | 1.6/3.6 | [30] |
SPE-LVSS-CE | 19 | 9.2/7.0 | [31] |
MSPE-CE | 2 | 1.7/2.2 | [32] |
SPME-LVSS-CE-DAD | 70 (68 µg kg−1) | 3.5/4.5 | This work |
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Share and Cite
Ferreira, T.A.; Flores-Aguilar, J.F.; Santos, E.M.; Rodriguez, J.A.; Ibarra, I.S. New Poly(Ionic Liquid) Based Fiber for Determination of Oxytetracycline in Milk Samples by Application of SPME-CE Technique. Molecules 2019, 24, 430. https://doi.org/10.3390/molecules24030430
Ferreira TA, Flores-Aguilar JF, Santos EM, Rodriguez JA, Ibarra IS. New Poly(Ionic Liquid) Based Fiber for Determination of Oxytetracycline in Milk Samples by Application of SPME-CE Technique. Molecules. 2019; 24(3):430. https://doi.org/10.3390/molecules24030430
Chicago/Turabian StyleFerreira, T. Alexandra, J. Francisco Flores-Aguilar, Eva M. Santos, Jose A. Rodriguez, and Israel S. Ibarra. 2019. "New Poly(Ionic Liquid) Based Fiber for Determination of Oxytetracycline in Milk Samples by Application of SPME-CE Technique" Molecules 24, no. 3: 430. https://doi.org/10.3390/molecules24030430