Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis
Abstract
:1. Introduction
2. Results and Discussion
2.1. Composition and Structure of Nanoparticles
2.2. NP Coating with Polysaccharides
2.3. Magnetic Properties
2.4. Optical Properties
2.5. Cytotoxicity
2.6. MR and Optical Imaging
3. Experimental
3.1. Chemicals
3.2. Preparation of NPs
3.2.1. Bare NPs
3.2.2. Fucoidan Coating
3.2.3. Carboxymethyl Dextran Coating
3.3. Iron and Zinc Concentration
3.4. Fucoidan Content
3.5. X-Ray Diffractometry
3.6. Transmission Electronic Microscopy
3.7. High-Resolution Transmission Electron Microscopy and Energy-Dispersive X-Ray Spectroscopy Analysis
3.8. FT-IR Spectroscopy
3.9. Thermogravimetric Analysis
3.10. Particle Size Analysis and Isoelectric Point Analysis
3.11. Magnetic Properties
3.12. Relaxivity
3.13. UV-Visible Spectroscopy
3.14. Cell Experiments
3.15. Animal Study
3.16. MRI Session
3.17. Optical Imaging
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Availability: Samples of the compounds are not available. |
RFe,i | RFe,f a | TEM | XRD | Stoichiometry b | ||
---|---|---|---|---|---|---|
Size (nm) | PDI | Size (nm) | Lattice Parameters | |||
0.05 | 0.06 | 7.0 ± 0.8 | 0.11 | 5.9 ± 0.2 | Wurtzite a: 0.325839 ± 6.68 × 10−5 c: 0.53225 ± 2.05 × 10−5 | Fe0.06Zn0.94O |
0.15 | 0.18 | 7.0 ± 1.0 | 0.14 | 6.7 ± 0.2 | Wurtzite a: 0.327126 ± 4.6 × 10−5 nm c: 0.52281 ± 1.156 × 10−5 nm | Fe0.18Zn0.82O |
0.35 | 0.42 | 6.3 ± 0.2 | 0.03 | 5.8 ± 0.2 | Wurtzite a: 0.327094 ± 2.83 × 10−5 nm c: 0.531681 ± 2.83 × 10−5 nm | Fe0.42Zn0.58O |
0.50 | 0.57 | 4.2 ± 0.6 | 0.14 | 4.1 ± 0.1 | Wurtzite a: 0.32499 ± 1.78 × 10−4 nm c: 0.530024 ± 3.87 × 10−4 nm | Fe0.54Zn0.46O c 44.9% (w/w) |
3.8 ± 0.4 | Cubic a: 0.84752 ± 1.15 × 10−4 nm | ZnFe2O4 d 55.1% (w/w) |
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Nguyen, H.; Tinet, E.; Chauveau, T.; Geinguenaud, F.; Lalatonne, Y.; Michel, A.; Aid-Launais, R.; Journé, C.; Lefèbvre, C.; Simon-Yarza, T.; et al. Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis. Molecules 2019, 24, 962. https://doi.org/10.3390/molecules24050962
Nguyen H, Tinet E, Chauveau T, Geinguenaud F, Lalatonne Y, Michel A, Aid-Launais R, Journé C, Lefèbvre C, Simon-Yarza T, et al. Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis. Molecules. 2019; 24(5):962. https://doi.org/10.3390/molecules24050962
Chicago/Turabian StyleNguyen, Hoang, Eric Tinet, Thierry Chauveau, Frédéric Geinguenaud, Yoann Lalatonne, Aude Michel, Rachida Aid-Launais, Clément Journé, Caroline Lefèbvre, Teresa Simon-Yarza, and et al. 2019. "Bimodal Fucoidan-Coated Zinc Oxide/Iron Oxide-Based Nanoparticles for the Imaging of Atherothrombosis" Molecules 24, no. 5: 962. https://doi.org/10.3390/molecules24050962