Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels
Abstract
:1. Introduction
2. Results
2.1. Impact of Ultrasonic Intensity and Duration on Therapeutic Release from Ca2+ Crosslinked Hydrogels
2.2. Erosion and Heating of Scaffold Due to Ultrasound Stimulation
2.3. Triggered Therapeutic Delivery by Pulsing the Ultrasound Stimulation
2.4. Ultrasonically Generating Pulsatile Therapeutic Delivery Profiles
2.5. Sequential 5-Fluorouracil and Irinotecan Delivery On Melanoma Cells in Vitro
2.6. Generation of the Sequential 5-Fluorouracil and Irinotecan Deliveries
3. Discussion
4. Materials and Methods
4.1. Materials
4.2. Calcium Crosslinked Hydrogel Fabrication
4.3. Release Studies
4.4. Sequential Release Studies
4.5. Data Representation and Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Emi, T.; Michaud, K.; Orton, E.; Santilli, G.; Linh, C.; O’Connell, M.; Issa, F.; Kennedy, S. Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels. Molecules 2019, 24, 1048. https://doi.org/10.3390/molecules24061048
Emi T, Michaud K, Orton E, Santilli G, Linh C, O’Connell M, Issa F, Kennedy S. Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels. Molecules. 2019; 24(6):1048. https://doi.org/10.3390/molecules24061048
Chicago/Turabian StyleEmi, Tania, Kendra Michaud, Emma Orton, Grace Santilli, Catherine Linh, Meaghan O’Connell, Fatima Issa, and Stephen Kennedy. 2019. "Ultrasonic Generation of Pulsatile and Sequential Therapeutic Delivery Profiles from Calcium-Crosslinked Alginate Hydrogels" Molecules 24, no. 6: 1048. https://doi.org/10.3390/molecules24061048