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Molecules
Volume 25
Issue 21
10.3390/molecules25215066
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Article
Peer-Review Record

Two-Photon Polymerized Poly(2-Ethyl-2-Oxazoline) Hydrogel 3D Microstructures with Tunable Mechanical Properties for Tissue Engineering

Molecules 2020, 25(21), 5066; https://doi.org/10.3390/molecules25215066
by Steffen Czich 1,†, Thomas Wloka 2,3,†, Holger Rothe 1, Jürgen Rost 1, Felix Penzold 1, Maximilian Kleinsteuber 2,3, Michael Gottschaldt 2,3, Ulrich S. Schubert 2,3 and Klaus Liefeith 1,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Molecules 2020, 25(21), 5066; https://doi.org/10.3390/molecules25215066
Submission received: 5 October 2020 / Revised: 23 October 2020 / Accepted: 26 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Polymer Scaffolds for Biomedical Applications 2020)

Round 1

Reviewer 1 Report

COMMENTS [Article ID: molecules-973011]
This paper reports a study concerning hydrogels produced via two-photon polymerization. This study encompasses a characterization of the properties of the produced hydrogels concerning the swelling behaviour, mechanical properties and structural integrity. It is recommended for publication in Molecules after minor revision indicated below.

  1. Revise the overall manuscript since there are some typos.
  2. The main novelty of the study should be mentioned clearly.
  3. Please describe better the mechanical evaluation concerning nanoindentation (indentation time, material for the indentor, analytical measure used, etc.).
  4. Please unify the format of the references. For example, page numbers from reference number 9 was included as “745-59”, whereas for other references appears complete.

Author Response

Please see attachment

Author Response File: Author Response.docx

Reviewer 2 Report

The work by Czich and colleagues introduce a hydrogel system based on poly(2-ethyl-2-oxazoline)s that can be polymerized via 2-photon radiation.  They utilize an interesting evaluation approach to assess structural fidelity of polymerized constructs in a binarized manner. While the work has several significant and innovative aspects, there are a number of minor issues that the authors should address in order to further improve the quality of the data presentation.

1- Figures 2-3: are presented too large, with font sizes that are too large and not proportional to the rest of the manuscript text size. Also, I suggest combining figures 1-3 into one figure with multiple panels to consolidate all characterization data in one place.

2- Please report 'n' for all the graphs and qualitative data presented in the manuscript. Further, statistical analysis must be performed for all quantitative assays and reported in the figures and figure captions. For instance, in figure 4 plots, stats are missing. Same story in the Figure 6.

3- Make sure to properly introduce all the acronyms that are used in this study, which is quite a few. For instance, '2PP', 'ECM', and 'CAD" in the Abstract have not been properly defined.

Author Response

Please see attachment

Author Response File: Author Response.docx

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