Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies
Abstract
:1. Introduction
2. Results and Discussion
2.1. Stoichiometry Determination of RSP/CD Inclusion Complexes
2.2. Molecular Modeling Studies
2.3. X-ray Diffraction Studies
2.4. Thermal Metods
2.5. FTIR Spectroscopy
2.6. Solubility Profile of RSP/CD Kneaded Products
3. Materials and Methods
3.1. Materials
3.2. Stoichiometry Determination of RSP/CD Inclusion Complexes
3.3. Molecular Modeling Studies
3.4. Preparation of the Solid Inclusion Complexes and Physical Mixtures
3.5. X-ray Diffraction Studies
3.6. Thermal Metods
3.7. FTIR Spectroscopy
3.8. Solubility Profile of RSP/CD Kneaded Products
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Sbârcea, L.; Tănase, I.-M.; Ledeți, A.; Cîrcioban, D.; Vlase, G.; Barvinschi, P.; Miclău, M.; Văruţ, R.-M.; Trandafirescu, C.; Ledeți, I. Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies. Molecules 2020, 25, 5694. https://doi.org/10.3390/molecules25235694
Sbârcea L, Tănase I-M, Ledeți A, Cîrcioban D, Vlase G, Barvinschi P, Miclău M, Văruţ R-M, Trandafirescu C, Ledeți I. Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies. Molecules. 2020; 25(23):5694. https://doi.org/10.3390/molecules25235694
Chicago/Turabian StyleSbârcea, Laura, Ionuț-Mihai Tănase, Adriana Ledeți, Denisa Cîrcioban, Gabriela Vlase, Paul Barvinschi, Marinela Miclău, Renata-Maria Văruţ, Cristina Trandafirescu, and Ionuț Ledeți. 2020. "Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies" Molecules 25, no. 23: 5694. https://doi.org/10.3390/molecules25235694