The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
Abstract
:1. Introduction
2. The Relationship between Gut Microbiota and Nervous System
2.1. Neural Pathways
2.2. Immune Pathway
2.3. Neuroendocrine Pathway
2.4. Microbial Metabolite Pathway
2.5. Nitric Oxide Pathway
3. Disturbance of Gut Microbiota Leads to Neurodegeneration
4. Mechanisms of the Neuroprotective Effect of TPs
4.1. Antioxidation
4.1.1. Directly Scavenge Active Oxygen Free Radicals and Nitrogen Free Radicals
4.1.2. Inhibition to Oxidase Promotion and Lipid Peroxidation
4.1.3. Activate Intracellular Antioxidant Defense System
4.2. The Activity of the Metal Chelating Agent
4.3. Regulate Signal Pathway
4.3.1. Selectively Activate Protein kinase C (PKC) in Cerebral Neurons
4.3.2. Regulate Other Signal Transduction Pathways
4.3.3. Anti-Apoptosis
4.4. Regulate the Level of Neurotransmitters
4.5. Autophagy
5. The Reciprocal Interactions between TPs and Gut Microbiota Promote Nerve Protection
5.1. Biotransformation of TPs by Gut Microbiota
5.2. Regulatory Effect of TPs on Intestinal Flora
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Zhang, Z.; Zhang, Y.; Li, J.; Fu, C.; Zhang, X. The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora. Molecules 2021, 26, 3692. https://doi.org/10.3390/molecules26123692
Zhang Z, Zhang Y, Li J, Fu C, Zhang X. The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora. Molecules. 2021; 26(12):3692. https://doi.org/10.3390/molecules26123692
Chicago/Turabian StyleZhang, Zhicheng, Yuting Zhang, Junmin Li, Chengxin Fu, and Xin Zhang. 2021. "The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora" Molecules 26, no. 12: 3692. https://doi.org/10.3390/molecules26123692