Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles
Abstract
:1. Introduction
2. Results
3. Experimental
3.1. Chemistry
3.2. General Procedure for the Synthesis of 3-Phenyl-1H-indoles (3a–t)
3.3. Determination of the Minimum Inhibitory Concentration (MIC)
3.4. Cellular Evaluation
3.5. Genotoxicity
3.6. Time-Kill Curves
3.7. Pharmacodynamic Model
3.8. Statistical Analysis
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Compound | H37Rv (μM) | PT2 (μM) | PT12 (μM) | PT20 (μM) | CC50 a HepG2 (µM) | CC50 a Vero (µM) |
---|---|---|---|---|---|---|
3h | 18.2 | 4.5 | 9.1 | 9.1 | <30 | <30 |
3n | 17.2 | 17.2 | 17.2 | 17.2 | <30 | <30 |
3r | 19.4 | 9.7 | 19.4 | 19.4 | >30 | >30 |
3t | 8.4 | 8.4 | 8.4 | 8.4 | <30 | <30 |
INH | 2.3 | 291.7 | 36.4 | 145.8 | - | - |
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Jardim Etchart, R.; Rambo, R.S.; Lopes Abbadi, B.; Sperotto, N.; Ev Neves, C.; Fries Silva, F.; Dornelles, M.; Duarte, L.; Souza Macchi, F.; Alberton Perelló, M.; et al. Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles. Molecules 2021, 26, 5148. https://doi.org/10.3390/molecules26175148
Jardim Etchart R, Rambo RS, Lopes Abbadi B, Sperotto N, Ev Neves C, Fries Silva F, Dornelles M, Duarte L, Souza Macchi F, Alberton Perelló M, et al. Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles. Molecules. 2021; 26(17):5148. https://doi.org/10.3390/molecules26175148
Chicago/Turabian StyleJardim Etchart, Renata, Raoní S. Rambo, Bruno Lopes Abbadi, Nathalia Sperotto, Christiano Ev Neves, Fernanda Fries Silva, Maiele Dornelles, Lovaine Duarte, Fernanda Souza Macchi, Marcia Alberton Perelló, and et al. 2021. "Synthesis and Antimycobacterial Activity of 3-Phenyl-1H-indoles" Molecules 26, no. 17: 5148. https://doi.org/10.3390/molecules26175148