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Volume 26
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Review

From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones

by
Madalena M. M. Pinto
1,2,*,
Andreia Palmeira
1,2,†,
Carla Fernandes
1,2,†,
Diana I. S. P. Resende
1,2,†,
Emília Sousa
1,2,†,
Honorina Cidade
1,2,†,
Maria Elizabeth Tiritan
1,2,3,†,
Marta Correia-da-Silva
1,2,† and
Sara Cravo
1,2,†
1
Laboratory of Organic and Pharmaceutical Chemistry (LQOF), Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal
2
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal
3
CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
*
Author to whom correspondence should be addressed.
†
These authors (by alphabetic order) contributed equally to this work.
Molecules 2021, 26(2), 431; https://doi.org/10.3390/molecules26020431
Submission received: 16 December 2020 / Revised: 7 January 2021 / Accepted: 11 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Recent Contributions of Female Scientists to the Advancement of Medicinal Chemistry)
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Abstract

This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacological activities, formulation and analytical applications. Although her group activity has been spread over several chemical families with relevance in Medicinal Chemistry, the main focus of the investigation and research has been in the xanthone family. Xanthone derivatives have a variety of activities with great potential for therapeutic applications due to their versatile framework. The group has contributed with several libraries of xanthones derivatives, with a variety of activities such as antitumor, anticoagulant, antiplatelet, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective, antioxidant, and multidrug resistance reversal effects. Besides therapeutic applications, our group has also developed xanthone derivatives with analytical applications as chiral selectors for liquid chromatography and for maritime application as antifouling agents for marine paints. Chemically, it has been challenging to afford green chemistry methods and achieve enantiomeric purity of chiral derivatives. In this review, the structures of the most significant compounds will be presented.
Keywords: xanthones; thioxanthones; marine natural products; biological activities; synthesis; chiral xanthones; thioxanthones; marine natural products; biological activities; synthesis; chiral
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MDPI and ACS Style

Pinto, M.M.M.; Palmeira, A.; Fernandes, C.; Resende, D.I.S.P.; Sousa, E.; Cidade, H.; Tiritan, M.E.; Correia-da-Silva, M.; Cravo, S. From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones. Molecules 2021, 26, 431. https://doi.org/10.3390/molecules26020431

AMA Style

Pinto MMM, Palmeira A, Fernandes C, Resende DISP, Sousa E, Cidade H, Tiritan ME, Correia-da-Silva M, Cravo S. From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones. Molecules. 2021; 26(2):431. https://doi.org/10.3390/molecules26020431

Chicago/Turabian Style

Pinto, Madalena M. M., Andreia Palmeira, Carla Fernandes, Diana I. S. P. Resende, Emília Sousa, Honorina Cidade, Maria Elizabeth Tiritan, Marta Correia-da-Silva, and Sara Cravo. 2021. "From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones" Molecules 26, no. 2: 431. https://doi.org/10.3390/molecules26020431

APA Style

Pinto, M. M. M., Palmeira, A., Fernandes, C., Resende, D. I. S. P., Sousa, E., Cidade, H., Tiritan, M. E., Correia-da-Silva, M., & Cravo, S. (2021). From Natural Products to New Synthetic Small Molecules: A Journey through the World of Xanthones. Molecules, 26(2), 431. https://doi.org/10.3390/molecules26020431

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