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Article

Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C

by
Emilia Furia
1,
Amerigo Beneduci
1,*,
Luana Malacaria
1,
Alessia Fazio
2,
Chiara La Torre
2 and
Pierluigi Plastina
2
1
Department of Chemistry and Chemical Technologies, University of Calabria, 87036 Arcavacata di Rende, CS, Italy
2
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, CS, Italy
*
Author to whom correspondence should be addressed.
Molecules 2021, 26(21), 6500; https://doi.org/10.3390/molecules26216500
Submission received: 7 October 2021 / Revised: 25 October 2021 / Accepted: 27 October 2021 / Published: 28 October 2021
(This article belongs to the Special Issue New Insights into Thermodynamics of Solutes in Neat and Complex Solvents)
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Abstract

In this work, the solubility of vanillic, gallic, syringic, p-coumaric, ferulic and caffeic acids was determined at 37 °C under different conditions, namely pure water and two different ionic media, NaCl(aq) and NaClO4(aq), at different ionic strengths (i.e., 0.16, 0.50, 1.0, 2.0 and 3.0 M). The solubility in water of all the acids was found to be higher than that in both of the ionic media. Moreover, the solubility of hydroxycinnamic acids was lower than that of hydroxybenzoic acids. The activity coefficients of neutral species were calculated from these data; this knowledge is necessary when modeling the dependence of equilibrium constants on the ionic strength. Results obtained in this work can be useful for further studies regarding complex formation equilibria between these ligands and bioavailable metal cations.
Keywords: solubility; phenolic acids; activity coefficients; salting out constant; ionic medium solubility; phenolic acids; activity coefficients; salting out constant; ionic medium

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MDPI and ACS Style

Furia, E.; Beneduci, A.; Malacaria, L.; Fazio, A.; La Torre, C.; Plastina, P. Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C. Molecules 2021, 26, 6500. https://doi.org/10.3390/molecules26216500

AMA Style

Furia E, Beneduci A, Malacaria L, Fazio A, La Torre C, Plastina P. Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C. Molecules. 2021; 26(21):6500. https://doi.org/10.3390/molecules26216500

Chicago/Turabian Style

Furia, Emilia, Amerigo Beneduci, Luana Malacaria, Alessia Fazio, Chiara La Torre, and Pierluigi Plastina. 2021. "Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C" Molecules 26, no. 21: 6500. https://doi.org/10.3390/molecules26216500

APA Style

Furia, E., Beneduci, A., Malacaria, L., Fazio, A., La Torre, C., & Plastina, P. (2021). Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C. Molecules, 26(21), 6500. https://doi.org/10.3390/molecules26216500

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