Improved Synthesis of a Novel Biodegradable Tunable Micellar Polymer Based on Partially Hydrogenated Poly(β-malic Acid-co-benzyl Malate)
Abstract
:1. Introduction
2. Results and Discussion
2.1. Preparation of MLABn
2.2. Preparation of PBM
2.3. Crystallization Behaviors of PBM
2.4. Thermogravimetric Analysis of PBM
2.5. Degradation of PBM
2.6. Biocompatibility
2.7. Preparation of PMLA
2.8. Partial Hydrogenation of PBM
3. Materials and Methods
3.1. Materials
3.2. Measurement
3.3. Monomer Synthesis
3.3.1. Method 1
3.3.2. Method 2
3.4. Polymerization
3.5. Characterization of PBM
3.6. Degradation of PBM
3.7. In Vivo Inflammation Study
3.8. Cell Cycle Assay
3.9. Hydrogenation and Micellization of PBM
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
References
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Yu, Z.; Ren, H.; Zhang, Y.; Qiao, Y.; Wang, C.; Yang, T.; Wu, H. Improved Synthesis of a Novel Biodegradable Tunable Micellar Polymer Based on Partially Hydrogenated Poly(β-malic Acid-co-benzyl Malate). Molecules 2021, 26, 7169. https://doi.org/10.3390/molecules26237169
Yu Z, Ren H, Zhang Y, Qiao Y, Wang C, Yang T, Wu H. Improved Synthesis of a Novel Biodegradable Tunable Micellar Polymer Based on Partially Hydrogenated Poly(β-malic Acid-co-benzyl Malate). Molecules. 2021; 26(23):7169. https://doi.org/10.3390/molecules26237169
Chicago/Turabian StyleYu, Zhe, Haozhe Ren, Yu Zhang, Youbei Qiao, Chaoli Wang, Tiehong Yang, and Hong Wu. 2021. "Improved Synthesis of a Novel Biodegradable Tunable Micellar Polymer Based on Partially Hydrogenated Poly(β-malic Acid-co-benzyl Malate)" Molecules 26, no. 23: 7169. https://doi.org/10.3390/molecules26237169