Inhibitory Effects of Coumarin Derivatives on Tyrosinase
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis
2.2. Tyrosinase Inhibitory Activity
3. Materials and Methods
3.1. Materials
3.2. Synthesis
3.3. Tyrosinase Inhibition Assay
3.4. Statistical Analysis
4. Conclusions
Supplementary Materials
Funding
Conflicts of Interest
Sample Availability
References
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Compound | R1 | R2 | R3 | R4 | R5 | R6 | Yield (%) |
---|---|---|---|---|---|---|---|
3e | Geranyloxy | H | H | H | H | H | 87 |
3f | Ph | H | H | H | Geranyloxy | H | 92 |
3g | H | CH3 | H | H | Geranyloxy | H | 91 |
3h | H | CF3 | H | H | Geranyloxy | H | 90 |
3i | H | H | H | H | Geranyloxy | H | 94 |
3j | H | CH3 | H | Cl | Geranyloxy | H | 90 |
3k | H | CH3 | H | Geranyloxy | Geranyloxy | H | 86 |
3l | H | CH3 | H | Geranyloxy | H | H | 89 |
Compound | R1 | R2 | R | R4 | R5 | R6 |
---|---|---|---|---|---|---|
1e | OH | H | H | H | H | H |
1i | H | H | H | H | OH | H |
1j | H | CH3 | H | Cl | OH | H |
1k | H | CH3 | H | OH | OH | H |
1l | H | CH3 | H | OH | H | H |
1m | CN | H | H | H | OH | H |
1n | Cl | CH3 | H | H | OH | H |
1o | NO2 | OH | H | H | H | H |
1p | H | CH2COOH | H | H | OH | H |
1q | H | H | H | OH | H | H |
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Roh, E.-J. Inhibitory Effects of Coumarin Derivatives on Tyrosinase. Molecules 2021, 26, 2346. https://doi.org/10.3390/molecules26082346
Roh E-J. Inhibitory Effects of Coumarin Derivatives on Tyrosinase. Molecules. 2021; 26(8):2346. https://doi.org/10.3390/molecules26082346
Chicago/Turabian StyleRoh, Eon-Joo. 2021. "Inhibitory Effects of Coumarin Derivatives on Tyrosinase" Molecules 26, no. 8: 2346. https://doi.org/10.3390/molecules26082346