Peer-Review Record
Radiation-Induced Oxidation Reactions of 2-Selenouracil in Aqueous Solutions: Comparison with Sulfur Analog of Uracil
Molecules 2022, 27(1), 133; https://doi.org/10.3390/molecules27010133
by
Konrad Skotnicki 1,*, Ireneusz Janik 2,*
, Klaudia Sadowska 3, Grazyna Leszczynska 3 and Krzysztof Bobrowski 1
, Klaudia Sadowska 3, Grazyna Leszczynska 3 and Krzysztof Bobrowski 1Reviewer 1:
Anonymous
Reviewer 2:
Yang Lihua
Yang Lihua
Molecules 2022, 27(1), 133; https://doi.org/10.3390/molecules27010133
Submission received: 28 November 2021
/
Revised: 17 December 2021
/
Accepted: 20 December 2021
/
Published: 27 December 2021
(This article belongs to the Section Bioorganic Chemistry)
Round 1
Reviewer 1 Report
The subject of study is interesting and falls well within the scope of Journal. The manuscript is well written and the results are convincing. The theoretical methods used for calculations are reliable. Therefore in my opinion, this manuscript is suitable for publication in the current form.
Author Response
.
Reviewer 2 Report
This manuscript provides an experimental proof supported by the DFT method that character of primary and secondary reactive intermediates depends on the concentration of 2-SeU and pH of its aqueous solutions. The manuscript is well organized and deserved to be published after minor revision.
- The significance of this research should be stated.
- Why selected 2-SeU concentration at 0.05-1 mM, and pH at 4 and 7, the theoretic basis?
- The mechanism of why 2-SeU concentration and pH influencing the reactive intermediates should be discussed.
- The similarity of reactive intermediates observed during OH and N3-induced 2-SeU, as well as 2- SeU and 2-TU, should be concluded in the conclusion section.
Author Response
Please see the attachment
Author Response File: 
Author Response.pdf
