Polysaccharides from Medicine and Food Homology Materials: A Review on Their Extraction, Purification, Structure, and Biological Activities
Abstract
:1. Introduction
2. Extraction and Purification Methods for MFHPs
3. Structure–Activity Relationship of MFHPs
Sources | Purification Methods | Compound Name | Monosaccharide Composition | Analysis Technique | Chemical Structure | References |
---|---|---|---|---|---|---|
Chinese yam | Ultrafiltration | HSY-I, HSY-Ⅱ, HSY-Ⅲ | HSY-I: GluA:Gal = 1.86:5.19 HSY-Ⅱ: GluA:Ara:Rha:Glu:Gal = 0.81:1.24: 2.35:66.79:28.81 HSY-Ⅲ: Man:Glu:Gal = 13.20:12.79:74.0 | HPGPC, GC, FT–IR | 1 | [40] |
Ginger | DEAE-52 | HGP, EGP1, EGP2, UGP1, UGP2 | HGP: Glu EGP1: Man, Ara, Glu, Gal EGP2: Man, Rha, Ara, Gal, Xyl, Glu UGP1: Ara, Gal, Glu, Man UGP2: Man, Rha, Ara, Gal, Glu, Xyl | FT–IR, NMR | ND | [19] |
Pueraria lobata roots | DEAE-52 | PS-D1, PS-D2, PS-D3 | PS-D1: Glu:Fru = 24.4:1.0 PS-D2: Glu:Fru:Ara = 54.5:1.0:1.0 PS-D3: Glu:Fru:Gal:Ara = 61.0:1.0:2.7:2.4 | FT–IR, UV | ND | [41] |
Raspberry | Macroporous resin, Sephadex G-100 | RCP-II | GalA:Glu:Ara:Xyl:Rha:Gal = 1.00: 0.44:1.19:0.52:0.55:1.90 | GC, UV, FT–IR, NMR | ND | [24] |
Angelica dahurice roots | DEAE-52, Sephadex G-100 | ADPs-1a, ADPs-1b, ADPs-2, ADPs-3a, ADPs-3b | ADPs-1a: Glu, Man, Xyl, Gal = 26.1:0.22:0.31:0.11 ADPs-1b: Ara, Glu, Man, Xyl, Gal = 0.10:15.3:0.07:0.26:1.37 ADPs-2: Ara, Glu, Man, Xyl, Gal, Rha = 1.79:15.8:0.40:0.35:5.59:0.34 ADPs-3a: Ara, Glu, Man, Xyl, Gal, Rha = 2.01:1.68:0.41:0.13:4.97:1.06 ADPs-3b: Ara, Glu, Man, Xyl, Gal, Rha = 0.36:13.5:0.09:0.25:1.59:0.18 | HPSEC, GC, FT–IR, NMR | 2 | [42] |
Imperial Chrysanthemum | Sephadex G-200 | ICP-1 | Rha, Ara, Man, Glu, GluA, GalA = 1:0.70:1.14:1.48:0.81:1.67 | FT–IR, NMR, SEM, HPGPC | 3 | [43] |
Lotus | Sephadex G-100 | LLWP-1, LLWP-3 | LLWP-1: Rha, Glu, Gal, Ara, GalA = 7.0:6.0:28.0:24.8:26.4 LLWP-3: Rha, Glu, Gal, Ara, Man, GalA = 6.6:8.9:15.0:9.8:6.1:47.2 | HPAEC–PAD, FT–IR, | ND | [44] |
Turmeric | DEAE-52 | TPS-0, TPS-1, TPS-2, TPS-3 | TPS-0: Ara, Gal, Glu TPS-1: Ara, Gal, Glu TPS-2: Xyl, Glu, Gal, Ara, Rha, GalA, GluA TPS-3: Rha, Glu, Gal, Ara, Xyl, GalA, GluA | HPGPC, FT–IR, GC–MS, NMR, SEM | 4 | [16] |
Platycodon grandiflorus | Ultrafiltration | LMw-PGP | ND | HPGPC, FT–IR | ND | [45] |
Ganoderma lucidum | QFF anion-exchange column | GLP-1, GLP-2 | GLP:Man:Glc:Gal:Fuc = 4.9:63.5:26.2:5.4 GLP-2: Man:Glc:Gal = 1.6:90.6:7.8 | Agilent ZORBAX Eclipse XDB-C18 column, HPGPC, FT–IR, NMR | 5 | [33] |
Longan | DEAE-Sepharose | LPIIa | Rha, Rib, Ara, Xyl, Glu, Gal = 1.05:1:22.88:1.01:2.59:34.58 | GC–MS, APC, FT–IR, NMR, | 6 | [46] |
Dandelion | DEAE-Sepharose | PD1-1 | Glu, Man | HPGPC, GC–MS, UV, FT–IR, NMR | 7 | [39] |
Cistanche tubulosa | Ua-ternary ammonium salt precipitation | CTP | Rha, Man, Glu, Gal = 2.18:1:28.29:1.43 | FT–IR, CD, SEM, | ND | [47] |
Mulberry leaf | Sephadex G-100 | MLP | Ara, Xyl, Glu, Rha, Man = 1:2.13:6.53:1.04:8.73 | HPSEC, HPLC, FT–IR | ND | [48] |
Sea buckthorn | Sephacryl S-200 column | SP0.1-1 | Ara, Glu, Gal, Man = 11.2:2.3:1.9:1 | HPGPC, GC–MS, NMR, | 8 | [49] |
Amomum villosum Lour | DEAE-52, Sephadex G-100 | AVPG-1, AVPG-2 | AVPG-1: Glucose, Galactose, Xylose, Arabinose, GluA = 73.11:10.29:6.21:8.83:1.57 AVPG-2:Rha, Glu, Gal, Xyl, Ara, Glu GalA = 3.11:40.23:17.82:12.53:15.81:3.99 | HPSEC, SEM, GC–MS, NMR, FT–IR | 9 | [50] |
Gastrodia elata | Membrane separation | GEP-1 | Glc | GC–MS, FT–IR, NMR, SEM | 10 | [51] |
Dendrobium officinale | DEAE-52, Sephacryl S-300 | DOPA-1, DOPA-2 | DOPA-1: Man:Glu = 5.8:1 DOPA-2: Man, Glu = 4.5:1 | HPGPC, FT–IR, GC–MS, NMR | 11 | [52] |
Phyllanthus emblica | DEAE-52, Sephadex G-100 | PEPW80-1 | Rha, Arab, Gal = 3.02:1.00:4.23 | HPAEC–PAD, GC, FT–IR, NMR, SEM | 12 | [34] |
Houttuynia cordata | Sephacryl S-300, DEAE Cellulose | HCA4S1 | Rha, GalA, Gal, Ara = 15.6:17.5:41.2:25.7 | HPGPC, UV, GC, FT–IR, NMR, | 13 | [53] |
Polygonatum sibiricum | DEAE-Sepharose | PSP1, PSP2, PSP3, PSP4 | PSP1: Man:Glu:Gal = 14.96:2.13:82.91 PSP2: Rha:Glu:Gal:Xyl = 20.54:2.06:74.37:3.03 PSP3: Man:Rha:Glu:Gal:Xyl = 1.38:57.69:2.02:37.17:1.74 PSP4: Man:Rha:Gal:Xyl = 2.00:72.63:20.74:4.63 | HPSEC, FT–IR, NMR | ND | [54] |
4. Biological Activities of MFHPs
4.1. Hypoglycemic Activity
4.2. Hypolipidemic Activity
4.3. Antioxidant Activity
4.4. Anti-Tumor Activity
4.5. Immunomodulating Activity
4.6. Protective Effect of the Intestinal Barrier
4.7. Anti-Inflammatory Activity
4.8. Antiviral Activity
4.9. Other Activities
5. Concluding Remarks and Prospects
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Ethical Statement
References
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Source | Extraction Methods | Extraction Conditions | Yield /% | Reference |
---|---|---|---|---|
Turmeric | HWE | Extraction temperature of 60–100 °C, liquid-to-material ratio of 5–25 mL/g, extraction time of 1–3 h, and extraction times of 1–3 | 2.23 | [16] |
Angelica sinensis | HWE | Liquid-to-material ratio of 5 mL/g, extraction time of 130 min, and extraction times of 5 | 5.60 | [17] |
Chinese yam | HWE | Extraction temperature of 100 °C, liquid-to-material ratio of 5 mL/g, extraction time of 3 h | 5.71 | [18] |
Ginger | HWE | Extraction temperature of 100 °C, extraction time of 4 h, and liquid-to-material ratio of 20 mL/g | 11.74 | [19] |
Cassia | HWE | Extraction temperature of 80 °C, extraction time of 3.5 h | 5.46 | [20] |
Lentils | ACE | pH 4, extraction temperature 100 °C, extraction time 90 min | 23.30 | [32] |
Ginger | EAE | 20,000 U/g pectinase, 63,000 U/g cellulase, and 62.5 U/g papain, extraction temperature 40 °C, pH 7.0, and extraction time 2 h | 7.00 | [19] |
Raspberry | EAE | Pectinase:cellulase:papain of 2.5:1.7:2.1 (g/g/g), pH 4.0, liquid-to-solid ratio of 10:1 mL/g, extraction temperature of 55 °C, and extraction time of 2.6 h | 4.09 | [24] |
Angelica sinensis | MAE | Microwave power of 500 W, liquid-to-solid ratio of 51 mL/g, and extraction time of 20 min | 7.82 | [27] |
Cassia seed | MAE | Microwave power of 415 W, liquid-to-solid ratio of 51 mL/g, and extraction time of 7 min | 8.02 | [26] |
Coix seeds | UAE | Ultrasonic power 480 W, extraction temperature 80 °C, liquid-to-solid ratio 21 mL/g, and extraction time 16 min | 8.34 | [29] |
Dendrobium officinale | UAE | Ultrasonic power 144 W, extraction temperature 80 °C, liquid-to-material ratio 60 mL/g, and extraction time 3 h | 10.29 | [30] |
Lycium barbarum | UAE | Ultrasonic power 185 W, extraction temperature 73 °C, liquid-to-material ratio 38 mL/g, and extraction time 80 min | 12.54 | [31] |
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Xu, J.; Zhang, J.; Sang, Y.; Wei, Y.; Chen, X.; Wang, Y.; Xue, H. Polysaccharides from Medicine and Food Homology Materials: A Review on Their Extraction, Purification, Structure, and Biological Activities. Molecules 2022, 27, 3215. https://doi.org/10.3390/molecules27103215
Xu J, Zhang J, Sang Y, Wei Y, Chen X, Wang Y, Xue H. Polysaccharides from Medicine and Food Homology Materials: A Review on Their Extraction, Purification, Structure, and Biological Activities. Molecules. 2022; 27(10):3215. https://doi.org/10.3390/molecules27103215
Chicago/Turabian StyleXu, Jiaqi, Jinling Zhang, Yumei Sang, Yaning Wei, Xingyue Chen, Yuanxin Wang, and Hongkun Xue. 2022. "Polysaccharides from Medicine and Food Homology Materials: A Review on Their Extraction, Purification, Structure, and Biological Activities" Molecules 27, no. 10: 3215. https://doi.org/10.3390/molecules27103215