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Article

Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)

by
Bosco Peron Leutcha
1,2,
Jean Paul Dzoyem
3,
Jean-Bosco Jouda
4,
Denis Kehdinga Sema
1,
Virginie Flaure Tsague Tankeu
1,
Gabin Thierry Mbahbou Bitchagno
5,6,
Billy Toussie Tchegnitegni
2,5,6,
Flaure Rosette Ehawa Essoung
7,
Bruno Ndjakou Lenta
2,
Siméon Fogue Kouam
2,
Florence Delie
8,
Alain Meli Lannang
4,9,* and
Norbert Sewald
6,*
1
Department of Chemistry, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon
2
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé P.O. Box 47, Cameroon
3
Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
4
Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Ngaoundéré P.O. Box 454, Cameroon
5
Department of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon
6
Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, 33501 Bielefeld, Germany
7
University Institute of Technology, University of Ngaoundere, Ngaoundere P.O. Box 455, Cameroon
8
Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland
9
Department of Chemistry, Higher Teacher Training College, University of Maroua, Maroua P.O. Box 55, Cameroon
*
Authors to whom correspondence should be addressed.
Molecules 2022, 27(15), 4823; https://doi.org/10.3390/molecules27154823
Submission received: 27 June 2022 / Revised: 16 July 2022 / Accepted: 27 July 2022 / Published: 28 July 2022
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Abstract

Twenty-two compounds were isolated from the fruit of Albizia lebbeck including one unprecedented, rare amino acid-derived zwitterionic and one new flavone derivative. The isolation was performed on repeated column chromatography over silica gel and their structures were determined by 1D-, 2D-NMR and HR-ESI-MS spectra together with reported data in the literature. The chemophenetic significance is also discussed. Some isolated compounds were reported for the first time to be found in the species. Additionally, compound 2 showed antibacterial activity and compounds 1 and 2 revealed moderate cytotoxic activity against the Raw 264.7 cancer cell line with IC50 values of 37.19 µM and 29.36 µM, respectively. Furthermore, a proposed biosynthetic pathway of compound 1 is described.
Keywords: Albizia lebbeck; Acacia; Fabaceae; carbamide; flavonoids; antimicrobial activity; cytotoxicity Albizia lebbeck; Acacia; Fabaceae; carbamide; flavonoids; antimicrobial activity; cytotoxicity

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MDPI and ACS Style

Leutcha, B.P.; Dzoyem, J.P.; Jouda, J.-B.; Sema, D.K.; Tsague Tankeu, V.F.; Bitchagno, G.T.M.; Tchegnitegni, B.T.; Essoung, F.R.E.; Ndjakou Lenta, B.; Fogue Kouam, S.; et al. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules 2022, 27, 4823. https://doi.org/10.3390/molecules27154823

AMA Style

Leutcha BP, Dzoyem JP, Jouda J-B, Sema DK, Tsague Tankeu VF, Bitchagno GTM, Tchegnitegni BT, Essoung FRE, Ndjakou Lenta B, Fogue Kouam S, et al. Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules. 2022; 27(15):4823. https://doi.org/10.3390/molecules27154823

Chicago/Turabian Style

Leutcha, Bosco Peron, Jean Paul Dzoyem, Jean-Bosco Jouda, Denis Kehdinga Sema, Virginie Flaure Tsague Tankeu, Gabin Thierry Mbahbou Bitchagno, Billy Toussie Tchegnitegni, Flaure Rosette Ehawa Essoung, Bruno Ndjakou Lenta, Siméon Fogue Kouam, and et al. 2022. "Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae)" Molecules 27, no. 15: 4823. https://doi.org/10.3390/molecules27154823

APA Style

Leutcha, B. P., Dzoyem, J. P., Jouda, J.-B., Sema, D. K., Tsague Tankeu, V. F., Bitchagno, G. T. M., Tchegnitegni, B. T., Essoung, F. R. E., Ndjakou Lenta, B., Fogue Kouam, S., Delie, F., Meli Lannang, A., & Sewald, N. (2022). Antimicrobial and Cytotoxic Activities of Constituents from the Fruit of Albizia lebbeck L. Benth (Fabaceae). Molecules, 27(15), 4823. https://doi.org/10.3390/molecules27154823

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