Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway
Abstract
:1. Introduction
2. Results
2.1. Determination of Total Phenolic Acids Content in Chebulae Fructus Immaturus Extract
2.2. XQG Ameliorated II/R Induced Intestinal Morphological Damage
2.3. XQG Ameliorated II/R-Induced Intestinal Barrier Injury
2.4. XQG Alleviated II/R-Induced Oxidative Stress and the Inflammatory Response
2.5. XQG Alleviated II/R-Induced Cell Apoptosis
2.6. XQG Pretreatment Alters Gene Expression in II/R Mice
2.7. XQG Alleviated II/R-Induced Injury via the PPARα/NF-κB Signaling Pathway
3. Discussion
4. Materials and Methods
4.1. Main Instruments and Reagents
4.2. Animals
4.3. Histopathological Examination
4.4. Biochemical Indicators Detection
4.5. Immunohistochemical Analysis
4.6. Transcriptome Sequencing
4.7. Western Blot
4.8. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Sample Availability
References
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Liu, J.; Li, B.; Liu, J.; Qiu, F.; Diao, Y.; Lei, Y.; Liu, J.; Zhang, W. Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway. Molecules 2022, 27, 5227. https://doi.org/10.3390/molecules27165227
Liu J, Li B, Liu J, Qiu F, Diao Y, Lei Y, Liu J, Zhang W. Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway. Molecules. 2022; 27(16):5227. https://doi.org/10.3390/molecules27165227
Chicago/Turabian StyleLiu, Junjie, Bin Li, Jing Liu, Feng Qiu, Yunpeng Diao, Yuxin Lei, Jianjun Liu, and Wei Zhang. 2022. "Phenolic Acids from Fructus Chebulae Immaturus Alleviate Intestinal Ischemia-Reperfusion Injury in Mice through the PPARα/NF-κB Pathway" Molecules 27, no. 16: 5227. https://doi.org/10.3390/molecules27165227