Structural Characterization of Cis– and Trans–Pt(NH3)2Cl2 Conjugations with Chitosan Nanoparticles
Abstract
:1. Introduction
2. Results and Discussion
2.1. Stability of Drug–Chitosan Complexes by UV Spectroscopy
2.2. Thermodynamic Analysis of Drug–Chitosan Adducts
2.3. FTIR Spectra of Pt Drug–Chitosan Complexes
3. Materials and Methods
3.1. Materials
3.1.1. Preparation of Cis– and Trans–Pt Adducts with Chitosan Nanoparticles
3.1.2. UV–Visible Spectroscopy
3.1.3. FTIR Spectroscopy
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Sample Availability
Abbreviations
Ch | chitosan |
cis– and trans–Pt | Cis– and trans–Pt(NH3)2Cl2 |
FTIR | Fourier transform Infrared |
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Complexes | Temperature (K) | Binding Constant K (mol/L)−1 |
---|---|---|
298.15 | 1.44 × 105 | |
Cis–Pt–Ch–15 | 308.15 | 1.24 × 105 |
318.15 | 1.02 × 105 | |
298.15 | 1.89 × 105 | |
Cis–Pt–Ch–100 | 308.15 | 1.23 × 105 |
318.15 | 9.39 × 104 | |
298.15 | 9.84 × 104 | |
Trans–Pt–Ch–15 | 308.15 | 8.44 × 104 |
318.15 | 7.63 × 104 | |
298.15 | 1.14 × 105 | |
Trans–Pt–Ch–100 | 308.15 | 1.01 × 105 |
318.15 | 8.50 × 104 |
Thermodynamic Parameters | ||||
---|---|---|---|---|
Complexes | ΔH0 (kJ. mol−1) | ΔS0 (J. mol−1. K−1) | TΔS0 (kJ. mol−1) | ΔG0 (kJ. mol−1) |
6.91 | −12.80 (298.15 K) | |||
Cis–Pt–Ch–15 | −5.89 | 23.18 | 7.14 | −13.03 (308.15 K) |
7.37 | −13.26 (318.15 K) | |||
1.07 | −13.05 (298.15 K) | |||
Cis–Pt–Ch–100 | −11.98 | 3.59 | 1.11 | −13.09 (308.15 K) |
1.14 | −13.13 (318.15 K) | |||
8.02 | −12.37 (298.15 K) | |||
Trans–Pt–Ch–15 | −4.35 | 26.88 | 8.28 | −12.64 (308.15 K) |
8.55 | −12.91 (318.15 K) | |||
7.54 | −12.54 (298.15 K) | |||
Trans–Pt–Ch–100 | −5.00 | 25.3 | 7.79 | −12.80 (308.15 K) |
8.05 | −13.05 (318.15 K) |
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Chanphai, P.; Bérubé, G.; Tajmir-Riahi, H.-A. Structural Characterization of Cis– and Trans–Pt(NH3)2Cl2 Conjugations with Chitosan Nanoparticles. Molecules 2022, 27, 6264. https://doi.org/10.3390/molecules27196264
Chanphai P, Bérubé G, Tajmir-Riahi H-A. Structural Characterization of Cis– and Trans–Pt(NH3)2Cl2 Conjugations with Chitosan Nanoparticles. Molecules. 2022; 27(19):6264. https://doi.org/10.3390/molecules27196264
Chicago/Turabian StyleChanphai, Penparapa, Gervais Bérubé, and Heidar-Ali Tajmir-Riahi. 2022. "Structural Characterization of Cis– and Trans–Pt(NH3)2Cl2 Conjugations with Chitosan Nanoparticles" Molecules 27, no. 19: 6264. https://doi.org/10.3390/molecules27196264