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Article
Peer-Review Record

An Oxidation Study of Phthalimide-Derived Hydroxylactams

Molecules 2022, 27(2), 548; https://doi.org/10.3390/molecules27020548
by Bernard L. Adjei and Frederick A. Luzzio *
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Molecules 2022, 27(2), 548; https://doi.org/10.3390/molecules27020548
Submission received: 14 December 2021 / Revised: 9 January 2022 / Accepted: 11 January 2022 / Published: 15 January 2022

Round 1

Reviewer 1 Report

In this work, the authors reported an oxidation study of phthalimide-based hydroxylactams. However, the work is not matural for publication at current status. The following issues need to be fully addressed before resubmision.

  1. For characterization of the new compound 3, FT-IR is missing; also the original NMR spectra and FT-IR spectra need to be provided.
  2. Why the freshly prepared NiO2 is necessary, the oxidant needs to be fully characterized to identify the difference with commercially available sources. Further, how to reuse the oxidant?
  3. How about the other metal oxides such as iron oxides? Can they replace the NiO2?
  4. Can the process be converted to a catalytic process?

Author Response

Please See attached

Author Response File: Author Response.pdf

Reviewer 2 Report

Figure 1 and Scheme 1 should be compiled to the single scheme.

Application of similar-type catalytic systems in the organic synthesis should be shortly discussed.

Mobile phases for TLC experiments should be specified.

Paragraph 3.11
- Signals in the IR spectrum should be assigned specific molecular segments.
- Signals in NMR spectra should be assigned specific nuclei 

Author Response

Please See Attached

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

na

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