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Review

Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest

by
Haroon Khan
1,*,
Waqas Alam
1,
Khalaf F. Alsharif
2,
Michael Aschner
3,
Samreen Pervez
4 and
Luciano Saso
5
1
Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
2
Department of Clinical Laboratory, College of Applied Medical Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
3
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
4
Department of Pharmacy, Qurtuba University of Science and Information Technology, Peshawar 29050, Pakistan
5
Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Molecules 2022, 27(3), 920; https://doi.org/10.3390/molecules27030920
Submission received: 7 December 2021 / Revised: 21 January 2022 / Accepted: 25 January 2022 / Published: 28 January 2022
(This article belongs to the Special Issue Anticancer Properties of Natural and Derivative Products II)
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Abstract

Cancer is the second most fatal disease worldwide, with colon cancer being the third most prevalent and fatal form of cancer in several Western countries. The risk of acquisition of resistance to chemotherapy remains a significant hurdle in the management of various types of cancer, especially colon cancer. Therefore, it is essential to develop alternative treatment modalities. Naturally occurring alkaloids have been shown to regulate various mechanistic pathways linked to cell proliferation, cell cycle, and metastasis. This review aims to shed light on the potential of alkaloids as anti-colon-cancer chemotherapy agents that can modulate or arrest the cell cycle. Preclinical investigated alkaloids have shown anti-colon cancer activities and inhibition of cancer cell proliferation via cell cycle arrest at different stages, suggesting that alkaloids may have the potential to act as anticancer molecules.
Keywords: colon cancer; alkaloids; anticancer activity; cell cycle arrest colon cancer; alkaloids; anticancer activity; cell cycle arrest

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MDPI and ACS Style

Khan, H.; Alam, W.; Alsharif, K.F.; Aschner, M.; Pervez, S.; Saso, L. Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest. Molecules 2022, 27, 920. https://doi.org/10.3390/molecules27030920

AMA Style

Khan H, Alam W, Alsharif KF, Aschner M, Pervez S, Saso L. Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest. Molecules. 2022; 27(3):920. https://doi.org/10.3390/molecules27030920

Chicago/Turabian Style

Khan, Haroon, Waqas Alam, Khalaf F. Alsharif, Michael Aschner, Samreen Pervez, and Luciano Saso. 2022. "Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest" Molecules 27, no. 3: 920. https://doi.org/10.3390/molecules27030920

APA Style

Khan, H., Alam, W., Alsharif, K. F., Aschner, M., Pervez, S., & Saso, L. (2022). Alkaloids and Colon Cancer: Molecular Mechanisms and Therapeutic Implications for Cell Cycle Arrest. Molecules, 27(3), 920. https://doi.org/10.3390/molecules27030920

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