Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Entry | Conditions | Yields of 2a (%) |
---|---|---|
1 | mCPBA/toluene | 51 |
2 | mCPBA/dioxane | 32 |
3 | mCPBA/water | - |
4 | mCPBA/CHCl3 | 40 |
5 | mCPBA/DCM | 75 |
6 | mCPBA/THF a | 29 |
Solvent | Solvent Parameter | ||
---|---|---|---|
ε | HBA | π* | |
Toluene | 2.4 | - | 0.54 |
DCM | 9.1 | - | 0.82 |
CHCl3 | 4.8 | - | 0.58 |
Dioxane | 2.3 | 0.37 | 0.55 |
Water | 80 | 0.18 | 1.09 |
THF | 7.6 | 0.55 | 0.58 |
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Bukhari, S.N.A.; Ejaz, H.; Elsherif, M.A.; Janković, N. Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids. Molecules 2022, 27, 2939. https://doi.org/10.3390/molecules27092939
Bukhari SNA, Ejaz H, Elsherif MA, Janković N. Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids. Molecules. 2022; 27(9):2939. https://doi.org/10.3390/molecules27092939
Chicago/Turabian StyleBukhari, Syed Nasir Abbas, Hasan Ejaz, Mervat A. Elsherif, and Nenad Janković. 2022. "Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids" Molecules 27, no. 9: 2939. https://doi.org/10.3390/molecules27092939
APA StyleBukhari, S. N. A., Ejaz, H., Elsherif, M. A., & Janković, N. (2022). Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids. Molecules, 27(9), 2939. https://doi.org/10.3390/molecules27092939