New Synthetic Methodology for Drug-Like Molecules

Dear Colleagues,

Small-molecule drugs retain their importance in modern medicine, offering advantages in shelf life and manufacturing scalability in comparison to biologics. Attempts to define “drug-likeness,” most famously Lipinski’s rules in 1997 and their multiple variants, outline the most pressing synthetic targets for the methodologist. The synthesis of drug-like and fragment-like structures has driven the development of synthetic methodology over the past 50 years, and the advent of new synthetic strategies such as electrochemistry and photocatalysis ensures that a brisk pace of discovery has been maintained up to the present day.

This Special Issue aims to provide a broad overview of the most recent developments in synthetic methodology and chemical technologies (such as flow chemistry) which facilitate the synthesis of drug-like molecules. Contributions (including full papers, communications and reviews) which report new methodologies or techniques or provide an overview of synthetic strategies for forming drug- and fragment-like scaffolds are welcome.

Dr. Graeme Barker
Prof. Dr. Simona Rapposelli
Guest Editors

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