Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5
Abstract
:1. Introduction
2. Results and Discussion
3. Materials and Methods
3.1. General Experimental Procedures
3.2. Fungal Material
3.3. Fermentation, Extraction, and Isolation
3.4. X-ray Crystallographic Analysis
3.5. Quantum Chemistry Calculations
3.6. Biological Activity Assay
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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No. | 1 a | 2 a | 3 b | |||
---|---|---|---|---|---|---|
δH (J in Hz) | δC | δH (J in Hz) | δC | δH (J in Hz) | δC | |
1 | 194.0 | 194.6 | 199.4 | |||
2 | 2.42 (1H, m); 2.58 (1H, m) | 35.3 | 2.71 (1H, m); 2.56 (1H, m) | 22.5 | 2.63 (1H, m); 2.29 (1H, m) | 34.4 |
3 | 2.43 (1H, m); 2.36 (1H, m) | 31.1 | 2.46 (1H, m); 1.90 (1H, m) | 29.7 | 2.18 (1H, m); 1.97 (1H, m) | 30.6 |
4 | 4.75 (1H, dd, 9.0, 5.4) | 64.0 | 4.14 (1H, d, 4.8) | 71.7 | 4.38 (1H, td, 5.4, 2.4) | 67.1 |
5 | 178.5 | 180.6 | 174.9 | |||
6 | 115.1 | 111.3 | 113.2 | |||
7 | 5.25 (1H, dt, 6.0) | 79.4 | 5.65 (1H, d, 6.0) | 78.3 | 4.35 (1H, t, 2.4) | 65.4 |
8 | 5.25 (1H, dt, 6.0) | 89.5 | 5.05 (1H, d, 6.0) | 93.5 | 2.03 (1H, dt 14.4, 2.4); 1.55 (1H, m) | 29.3 |
9 | 4.35 (1H, d, 4.2) | 72.0 | 4.16 (1H, d, 4.8) | 74.6 | 4.14 (1H, td, 12.6, 2.4) | 78.2 |
10 | 3.66 (1H, m) | 82.1 | 3.43 (1H, td, 7.2) | 78.6 | 3.68 (1H, td, 12.6, 6.0) | 73.6 |
11 | 1.67 (2H, m) | 27.7 | 1.70 (1H, m); 1.64 (1H, m) | 27.1 | 1.64 (2H, m) | 33.8 |
12 | 1.29 (2H, m) | 26.1 | 1.31 (2H, m) | 26.0 | 1.55 (1H, m); 1.41 (1H, m) | 26.8 |
13 | 1.29 (2H, m) | 29.3 | 1.31 (2H, m) | 29.4 | 1.41 (1H, m); 1.33 (1H, m) | 30.6 |
14 | 1.29 (2H, m) | 31.7 | 1.31 (2H, m) | 31.6 | 1.33 (2H, m) | 33.2 |
15 | 1.29 (2H, m) | 22.6 | 1.31 (2H, m) | 22.7 | 1.33 (2H, m) | 23.8 |
16 | 0.87 (3H, t, 6.6) | 14.0 | 0.87 (3H, t, 7.2) | 14.0 | 0.91 (3H, t, 6.6) | 14.6 |
17 | 3.64 (1H, m); 3.55 (1H, m) | 65.4 | ||||
18 | 1.15 (3H, t, 6.6) | 16.0 |
No. | Exptl. δ | 1 | |
---|---|---|---|
1 | abs dev c | ||
1 | 194.0 | 192.84 | 1.16 |
2 | 35.3 | 34.53 | 0.77 |
3 | 31.1 | 29.98 | 1.12 |
4 | 64.0 | 64.25 | 0.25 |
5 | 178.5 | 177.16 | 1.34 |
6 | 115.1 | 119.53 | 4.43 |
7 | 79.4 | 79.34 | 0.06 |
8 | 89.5 | 89.96 | 0.46 |
9 | 72.0 | 74.36 | 2.36 |
11 | 82.1 | 79.27 | 2.83 |
12 | 27.7 | 28.77 | 1.07 |
13 | 26.1 | 25.42 | 0.68 |
14 | 29.3 | 28.92 | 0.38 |
15 | 31.7 | 30.87 | 0.83 |
16 | 22.6 | 22.83 | 0.23 |
MAE a | 1.15 | ||
RMS b | 1.60 | ||
Pmean | 30.45% | ||
Prel | 100% |
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Peng, W.; Tan, J.; Sang, Z.; Huang, Y.; Xu, L.; Zheng, Y.; Qin, S.; Tan, H.; Zou, Z. Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5. Molecules 2023, 28, 7848. https://doi.org/10.3390/molecules28237848
Peng W, Tan J, Sang Z, Huang Y, Xu L, Zheng Y, Qin S, Tan H, Zou Z. Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5. Molecules. 2023; 28(23):7848. https://doi.org/10.3390/molecules28237848
Chicago/Turabian StylePeng, Weiwei, Jianbing Tan, Zihuan Sang, Yuantao Huang, Li Xu, Yuting Zheng, Siyu Qin, Haibo Tan, and Zhenxing Zou. 2023. "Koninginins X-Z, Three New Polyketides from Trichoderma koningiopsis SC-5" Molecules 28, no. 23: 7848. https://doi.org/10.3390/molecules28237848