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Review

Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review

by
Iwona Rykowska
1,
Ola Michałkiewicz
1,*,
Iwona Nowak
1 and
Rafał Nowak
2
1
Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland
2
Department of Ophthalmology, Military Institute of Medicine, ul. Szaserów 128, 04-141 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(11), 2609; https://doi.org/10.3390/molecules29112609
Submission received: 30 April 2024 / Revised: 27 May 2024 / Accepted: 29 May 2024 / Published: 1 June 2024
(This article belongs to the Section Medicinal Chemistry)
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Abstract

The following review focuses on the manufacturing and parameterizing of ocular drug delivery systems (DDS) using polymeric materials to create soft contact lenses. It discusses the types of drugs embedded into contact lenses, the various polymeric materials used in their production, methods for assessing the mechanical properties of polymers, and techniques for studying drug release kinetics. The article also explores strategies for investigating the stability of active substances released from contact lenses. It specifically emphasizes the production of soft contact lenses modified with Cyclosporine A (CyA) for the topical treatment of specific ocular conditions. The review pays attention to methods for monitoring the stability of Cyclosporine A within the discussed DDS, as well as investigating the influence of polymer matrix type on the stability and release of CyA.
Keywords: therapeutic contact lenses; polymer matrix; drug stability; mechanic parameters; Cyclosporine A stability; drug delivery systems therapeutic contact lenses; polymer matrix; drug stability; mechanic parameters; Cyclosporine A stability; drug delivery systems

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MDPI and ACS Style

Rykowska, I.; Michałkiewicz, O.; Nowak, I.; Nowak, R. Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review. Molecules 2024, 29, 2609. https://doi.org/10.3390/molecules29112609

AMA Style

Rykowska I, Michałkiewicz O, Nowak I, Nowak R. Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review. Molecules. 2024; 29(11):2609. https://doi.org/10.3390/molecules29112609

Chicago/Turabian Style

Rykowska, Iwona, Ola Michałkiewicz, Iwona Nowak, and Rafał Nowak. 2024. "Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review" Molecules 29, no. 11: 2609. https://doi.org/10.3390/molecules29112609

APA Style

Rykowska, I., Michałkiewicz, O., Nowak, I., & Nowak, R. (2024). Drug-Modified Contact Lenses—Properties, Release Kinetics, and Stability of Active Substances with Particular Emphasis on Cyclosporine A: A Review. Molecules, 29(11), 2609. https://doi.org/10.3390/molecules29112609

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