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Article

Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens

by
Rashedul Islam
1,
Fahmida Habib Nabila
1,
Rie Wakabayashi
1,2,3,
Yoshirou Kawaguchi
1,
Noriho Kamiya
1,2,3,
Muhammad Moniruzzaman
4 and
Masahiro Goto
1,2,3,*
1
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka 819-0395, Japan
2
Advanced Transdermal Drug Delivery System Center, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka 819-0395, Japan
3
Division of Biotechnology, Center for Future Chemistry, Kyushu University, 744 Motooka, Nishi-Ku, Fukuoka 819-0395, Japan
4
Department of Chemical Engineering, Universiti Teknologi PETRONAS, Seri Iskandar 32610, Perak, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(13), 2995; https://doi.org/10.3390/molecules29132995
Submission received: 10 May 2024 / Revised: 14 June 2024 / Accepted: 16 June 2024 / Published: 24 June 2024
(This article belongs to the Section Molecular Liquids)
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Abstract

Herein, we report a transdermal patch prepared using an ionic liquid-based solid in oil (IL-S/O) nanodispersion and a pressure-sensitive adhesive (PSA) to deliver the macromolecular antigenic protein, ovalbumin (OVA). The IL-S/O nanodispersion and a PSA were first mixed at an equal weight ratio, then coated onto a release liner, and covered with a support film. To evaluate the effect of the PSA, three types of PSAs, DURO-TAK 87-4098, DURO-TAK 87-4287, and DURO-TAK 87-235A, were used to obtain the corresponding IL-S/O patches SP-4098, SP-4287, and SP-235A, respectively. The prepared IL-S/O patches were characterized for surface morphology, viscoelasticity, and moisture content. In vitro skin penetration and in vivo immunization studies of the IL-S/O patches were performed using Yucatan micropig skin and the C57BL/6NJc1 mice model, respectively. The SP-4098 and SP-4287 delivered 5.49-fold and 5.47-fold higher amounts of drug compared with the aqueous formulation. Although both patches delivered a similar amount of drug, SP-4287 was not detached fully from the release liner after 30 days, indicating low stability. Mice immunized with the OVA-containing SP-4098 produced a 10-fold increase in anti-OVA IgG compared with those treated with an aqueous formulation. These findings suggested that the IL-S/O patch may be a good platform for the transdermal delivery of antigen molecules.
Keywords: transdermal drug delivery; ionic liquid; pressure-sensitive adhesive; IL-S/O patch; immunization transdermal drug delivery; ionic liquid; pressure-sensitive adhesive; IL-S/O patch; immunization

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MDPI and ACS Style

Islam, R.; Nabila, F.H.; Wakabayashi, R.; Kawaguchi, Y.; Kamiya, N.; Moniruzzaman, M.; Goto, M. Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens. Molecules 2024, 29, 2995. https://doi.org/10.3390/molecules29132995

AMA Style

Islam R, Nabila FH, Wakabayashi R, Kawaguchi Y, Kamiya N, Moniruzzaman M, Goto M. Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens. Molecules. 2024; 29(13):2995. https://doi.org/10.3390/molecules29132995

Chicago/Turabian Style

Islam, Rashedul, Fahmida Habib Nabila, Rie Wakabayashi, Yoshirou Kawaguchi, Noriho Kamiya, Muhammad Moniruzzaman, and Masahiro Goto. 2024. "Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens" Molecules 29, no. 13: 2995. https://doi.org/10.3390/molecules29132995

APA Style

Islam, R., Nabila, F. H., Wakabayashi, R., Kawaguchi, Y., Kamiya, N., Moniruzzaman, M., & Goto, M. (2024). Ionic Liquid-Based Immunization Patch for the Transdermal Delivery of Antigens. Molecules, 29(13), 2995. https://doi.org/10.3390/molecules29132995

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