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Volume 29
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood–Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis

by
Giuliana Greco
1,†,
Aleksandra Agafonova
1,†,
Alessia Cosentino
1,
Nunzio Cardullo
2,
Vera Muccilli
2,
Carmelo Puglia
3,4,
Carmelina Daniela Anfuso
1,*,
Maria Grazia Sarpietro
3,4,* and
Gabriella Lupo
1
1
Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, 95123 Catania, Italy
2
Department of Chemical Sciences, University of Catania, 95125 Catania, Italy
3
Department of Drug and Health Sciences, University of Catania, 95125 Catania, Italy
4
NANOMED-Research Center on Nanomedicine and Pharmaceutical Nanotechnology, University of Catania, 95125 Catania, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2024, 29(13), 3103; https://doi.org/10.3390/molecules29133103 (registering DOI)
Submission received: 7 May 2024 / Revised: 12 June 2024 / Accepted: 24 June 2024 / Published: 28 June 2024
(This article belongs to the Special Issue Preparation, Characterization, and Effect of Lipid Nanoparticles Used in Different Application Fields IV)
Versions Notes

Abstract

Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process for cancer growth and development. Several studies have elucidated the synergistic relationship between angiogenesis and inflammation in various inflammatory diseases, highlighting a correlation between inflammation and vascular endothelial growth factor (VEGF)-induced angiogenesis. Thus, the identification of novel molecules capable of modulating VEGF effects presents promising prospects for developing therapies aimed at stabilizing, reversing, or even arresting disease progression. Lignans often suffer from low aqueous solubility and, for their use, encapsulation in a delivery system is needed. In this research, a bioinspired benzoxantene has been encapsulated in solid lipid nanoparticles that have been characterized for their pharmacotechnical properties and their thermotropic behavior. The effects of these encapsulated nanoparticles on angiogenic parameters and inflammation in VEGF-induced angiogenesis were evaluated using human brain microvascular endothelial cells (HBMECs) as a human blood–brain barrier model.
Keywords: SLNs; benzo[k,l]xanthene lignans; VEGF-induced angiogenesis; blood–brain barrier SLNs; benzo[k,l]xanthene lignans; VEGF-induced angiogenesis; blood–brain barrier

Share and Cite

MDPI and ACS Style

Greco, G.; Agafonova, A.; Cosentino, A.; Cardullo, N.; Muccilli, V.; Puglia, C.; Anfuso, C.D.; Sarpietro, M.G.; Lupo, G. Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood–Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis. Molecules 2024, 29, 3103. https://doi.org/10.3390/molecules29133103

AMA Style

Greco G, Agafonova A, Cosentino A, Cardullo N, Muccilli V, Puglia C, Anfuso CD, Sarpietro MG, Lupo G. Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood–Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis. Molecules. 2024; 29(13):3103. https://doi.org/10.3390/molecules29133103

Chicago/Turabian Style

Greco, Giuliana, Aleksandra Agafonova, Alessia Cosentino, Nunzio Cardullo, Vera Muccilli, Carmelo Puglia, Carmelina Daniela Anfuso, Maria Grazia Sarpietro, and Gabriella Lupo. 2024. "Solid Lipid Nanoparticles Encapsulating a Benzoxanthene Derivative in a Model of the Human Blood–Brain Barrier: Modulation of Angiogenic Parameters and Inflammation in Vascular Endothelial Growth Factor-Stimulated Angiogenesis" Molecules 29, no. 13: 3103. https://doi.org/10.3390/molecules29133103

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