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Recent Development of Fluoroquinolone Derivatives as Anticancer Agents
by
Justyna Nowakowska
Justyna Nowakowska 1,*,
Dominika Radomska
Dominika Radomska 2,
Robert Czarnomysy
Robert Czarnomysy 2 and
Krzysztof Marciniec
Krzysztof Marciniec 1,*
1
Department of Organic Chemistry, Medical University of Silesia, Jagiellonska 4, 41-200 Sosnowiec, Poland
2
Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland
*
Authors to whom correspondence should be addressed.
Molecules 2024, 29(15), 3538; https://doi.org/10.3390/molecules29153538 (registering DOI)
Submission received: 20 June 2024
/
Revised: 17 July 2024
/
Accepted: 25 July 2024
/
Published: 27 July 2024
Abstract
Cancer is the second leading cause of death in the world following cardiovascular disease. Its treatment, including radiation therapy and surgical removal of the tumour, is based on pharmacotherapy, which prompts a constant search for new and more effective drugs. There are high costs associated with designing, synthesising, and marketing new substances. Drug repositioning is an attractive solution. Fluoroquinolones make up a group of synthetic antibiotics with a broad spectrum of activity in bacterial diseases. Moreover, those compounds are of particular interest to researchers as a result of reports of their antiproliferative effects on the cells of the most lethal cancers. This article presents the current progress in the development of new fluoroquinolone derivatives with potential anticancer and cytotoxic activity, as well as structure–activity relationships, along with possible directions for further development.
Share and Cite
MDPI and ACS Style
Nowakowska, J.; Radomska, D.; Czarnomysy, R.; Marciniec, K.
Recent Development of Fluoroquinolone Derivatives as Anticancer Agents. Molecules 2024, 29, 3538.
https://doi.org/10.3390/molecules29153538
AMA Style
Nowakowska J, Radomska D, Czarnomysy R, Marciniec K.
Recent Development of Fluoroquinolone Derivatives as Anticancer Agents. Molecules. 2024; 29(15):3538.
https://doi.org/10.3390/molecules29153538
Chicago/Turabian Style
Nowakowska, Justyna, Dominika Radomska, Robert Czarnomysy, and Krzysztof Marciniec.
2024. "Recent Development of Fluoroquinolone Derivatives as Anticancer Agents" Molecules 29, no. 15: 3538.
https://doi.org/10.3390/molecules29153538
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