This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects
by
Maima Matin
Maima Matin 1,
Magdalena Koszarska
Magdalena Koszarska 1,
Atanas G. Atanasov
Atanas G. Atanasov 1,2,
Karolina Król-Szmajda
Karolina Król-Szmajda 1,
Artur Jóźwik
Artur Jóźwik
Dr Monika Hejna received a PhD degree in Veterinary and Animal Science from the University of Milan, [...]
Dr Monika Hejna received a PhD degree in Veterinary and Animal Science from the University of Milan, Italy, in 2021. In the meantime, she worked as a visiting scholar at the University of California, Davis, where she carried out the research on plant-based strategies of controlling antibiotics input in swine farming. To continue her postdoctoral research, M. Hejna moved to the University of Gdańsk, Poland. In 2022, she joined the PASIFIC Programme at the Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences.
1,
Adrian Stelmasiak
Adrian Stelmasiak 3 and
Monika Hejna
Monika Hejna 1,*
1
Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, 05-552 Jastrzębiec, Poland
2
Ludwig Boltzmann Institute Digital Health and Patient Safety, Medical University of Vienna, 1090 Vienna, Austria
3
Department of Technique and Food Development, Institute of Human Nutrition Sciences, University of Life Sciences of Warsaw, 02-787 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Molecules 2024, 29(19), 4695; https://doi.org/10.3390/molecules29194695 (registering DOI)
Submission received: 8 August 2024
/
Revised: 30 September 2024
/
Accepted: 1 October 2024
/
Published: 3 October 2024
Abstract
Algae, both micro- and macroalgae, are recognized for their rich repository of bioactive compounds with potential therapeutic applications. These marine organisms produce a variety of secondary metabolites that exhibit significant anti-inflammatory, antioxidant, and antimicrobial properties, offering promising avenues for the development of new drugs and nutraceuticals. Algae-derived compounds, including polyphenols, carotenoids, lipids, and polysaccharides, have demonstrated efficacy in modulating key inflammatory pathways, reducing oxidative stress, and inhibiting microbial growth. At the molecular level, these compounds influence macrophage activity, suppress the production of pro-inflammatory cytokines, and regulate apoptotic processes. Studies have shown that algae extracts can inhibit inflammatory signaling pathways such as NF-κB and MAPK, reduce oxidative damage by activating Nrf2, and offer an alternative to traditional antibiotics by combatting bacterial infections. Furthermore, algae’s therapeutic potential extends to addressing diseases such as cardiovascular disorders, neurodegenerative conditions, and cancer, with ongoing research exploring their efficacy in preclinical animal models. The pig model, due to its physiological similarities to humans, is highlighted as particularly suitable for validating the bioactivities of algal compounds in vivo. This review underscores the need for further investigation into the specific mechanisms of action and clinical applications of algae-derived biomolecules.
Share and Cite
MDPI and ACS Style
Matin, M.; Koszarska, M.; Atanasov, A.G.; Król-Szmajda, K.; Jóźwik, A.; Stelmasiak, A.; Hejna, M.
Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects. Molecules 2024, 29, 4695.
https://doi.org/10.3390/molecules29194695
AMA Style
Matin M, Koszarska M, Atanasov AG, Król-Szmajda K, Jóźwik A, Stelmasiak A, Hejna M.
Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects. Molecules. 2024; 29(19):4695.
https://doi.org/10.3390/molecules29194695
Chicago/Turabian Style
Matin, Maima, Magdalena Koszarska, Atanas G. Atanasov, Karolina Król-Szmajda, Artur Jóźwik, Adrian Stelmasiak, and Monika Hejna.
2024. "Bioactive Potential of Algae and Algae-Derived Compounds: Focus on Anti-Inflammatory, Antimicrobial, and Antioxidant Effects" Molecules 29, no. 19: 4695.
https://doi.org/10.3390/molecules29194695
Article Metrics
Article Access Statistics
For more information on the journal statistics, click
here.
Multiple requests from the same IP address are counted as one view.