Roles of PTEN with DNA Repair in Parkinson’s Disease
Abstract
:1. Introduction
2. DNA Damage and DNA Repair in Neurodegeneration
3. Association between PTEN and DNA Damage/DNA Repair Machinery in Neurodegenerative Diseases
4. Estrogen and Its Receptor Signaling with PTEN Involved in PD
5. Diets May Contribute to the Improved Neuron-Survival via the Modulation of PI3K/AKT/PTEN Signaling
6. Perspective
Acknowledgments
Conflicts of Interest
Abbreviations
ATM | ataxia telangiectasia mutated |
ATR | ataxia telangiectasia and Rad3 related |
BRCA1 | breast cancer susceptibility gene 1 |
DHA | docosahexaenoic acid |
ER | estrogen receptor |
n-3 PUFA | omega-3 polyunsaturated fatty acid |
NO | nitric oxide |
8-oxodG | 8-oxo-7,8-dihydro-2′-deoxyguanosine |
PD | Parkinson’s disease |
PI3K | Phosphoinositide 3-kinase |
PINK1 | PTEN-induced kinase 1 |
PTEN | phosphatase and tensin homolog on chromosome 10 |
PUFAs | polyunsaturated fatty acids |
ROS | reactive oxygen species |
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Ogino, M.; Ichimura, M.; Nakano, N.; Minami, A.; Kitagishi, Y.; Matsuda, S. Roles of PTEN with DNA Repair in Parkinson’s Disease. Int. J. Mol. Sci. 2016, 17, 954. https://doi.org/10.3390/ijms17060954
Ogino M, Ichimura M, Nakano N, Minami A, Kitagishi Y, Matsuda S. Roles of PTEN with DNA Repair in Parkinson’s Disease. International Journal of Molecular Sciences. 2016; 17(6):954. https://doi.org/10.3390/ijms17060954
Chicago/Turabian StyleOgino, Mako, Mayuko Ichimura, Noriko Nakano, Akari Minami, Yasuko Kitagishi, and Satoru Matsuda. 2016. "Roles of PTEN with DNA Repair in Parkinson’s Disease" International Journal of Molecular Sciences 17, no. 6: 954. https://doi.org/10.3390/ijms17060954