Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review

Coricovac, Dorina; Dehelean, Cristina; Moaca, Elena-Alina; Pinzaru, Iulia; Bratu, Tiberiu; Navolan, Dan; Boruga, Ovidiu

doi:10.3390/ijms19061566

Open AccessReview

Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review

by

Dorina Coricovac

^1,†

,

Cristina Dehelean

^1,†,

Elena-Alina Moaca

¹

,

Iulia Pinzaru

¹

,

Tiberiu Bratu

²,

Dan Navolan

^3,* and

Ovidiu Boruga

²

¹

Department of Toxicology, Faculty of Pharmacy, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timişoara, Romania

²

Faculty of Medicine, “Victor Babeş” University of Medicine and Pharmacy, 300041 Timişoara, Romania

³

Department of Obstetrics-Gynecology and Neonatology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timișoara, Romania

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2018, 19(6), 1566; https://doi.org/10.3390/ijms19061566

Submission received: 2 May 2018 / Revised: 21 May 2018 / Accepted: 22 May 2018 / Published: 24 May 2018

(This article belongs to the Special Issue Animal Models of Melanoma)

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Abstract

Cutaneous melanoma is a complex disorder characterized by an elevated degree of heterogeneity, features that place it among the most aggressive types of cancer. Although significant progress was recorded in both the understanding of melanoma biology and genetics, and in therapeutic approaches, this malignancy still represents a major problem worldwide due to its high incidence and the lack of a curative treatment for advanced stages. This review offers a survey of the most recent information available regarding the melanoma epidemiology, etiology, and genetic profile. Also discussed was the topic of cutaneous melanoma murine models outlining the role of these models in understanding the molecular pathways involved in melanoma initiation, progression, and metastasis.

Keywords: cutaneous melanoma; incidence; etiology; animal models; genetic profile

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MDPI and ACS Style

Coricovac, D.; Dehelean, C.; Moaca, E.-A.; Pinzaru, I.; Bratu, T.; Navolan, D.; Boruga, O. Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review. Int. J. Mol. Sci. 2018, 19, 1566. https://doi.org/10.3390/ijms19061566

AMA Style

Coricovac D, Dehelean C, Moaca E-A, Pinzaru I, Bratu T, Navolan D, Boruga O. Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review. International Journal of Molecular Sciences. 2018; 19(6):1566. https://doi.org/10.3390/ijms19061566

Chicago/Turabian Style

Coricovac, Dorina, Cristina Dehelean, Elena-Alina Moaca, Iulia Pinzaru, Tiberiu Bratu, Dan Navolan, and Ovidiu Boruga. 2018. "Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review" International Journal of Molecular Sciences 19, no. 6: 1566. https://doi.org/10.3390/ijms19061566

APA Style

Coricovac, D., Dehelean, C., Moaca, E.-A., Pinzaru, I., Bratu, T., Navolan, D., & Boruga, O. (2018). Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review. International Journal of Molecular Sciences, 19(6), 1566. https://doi.org/10.3390/ijms19061566

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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Cutaneous Melanoma—A Long Road from Experimental Models to Clinical Outcome: A Review

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