Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol
Abstract
:1. Introduction
2. Results
2.1. Synthesis
2.2. Crystal Structures of Complexes 1 and 2
2.3. Stability in Solution
2.4. In Vitro Cytotoxicity
2.5. Cell Cycle Analysis and Expressions of the Related Proteins
2.6. Apoptosis Assay
2.7. Loss of Mitochondrial Membrane Potential in MGC80-3 Cells
2.8. Intracellular Ca2+
2.9. Reactive Oxygen Species (ROS) Level
2.10. Western Blot Assay
2.11. Assessment of Caspase-3/9/8 Activation
3. Materials and Methods
3.1. Materials
3.2. Instrumentation
3.3. Synthesis
3.3.1. Synthesis of L
3.3.2. Synthesis of Complex 1
3.3.3. Synthesis of Complex 2
3.4. X-ray Crystallography
3.5. In Vitro Cytotoxicity
3.6. Cell Cycle Arrest
3.7. Other Experimental Methods
3.8. Statistics
4. Conclusions
Supplementary Materials
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Compounds | Hep-G2 | SK-OV-3 | MGC80-3 | HeLa | T-24 | BEL-7402 | NCI-H460 | HL-7702 |
---|---|---|---|---|---|---|---|---|
L | 58.40 ± 0.69 | 42.94 ± 2.64 | 40.93 ± 0.94 | 58.73 ± 1.29 | 85.93 ± 15.11 | 47.85 ± 0.37 | 36.93 ± 3.93 | 48.63 ± 0.34 |
1 | 4.51 ± 0.38 | 3.69 ± 0.16 | 2.60 ± 0.17 | 3.62 ± 0.12 | 4.41 ± 0.06 | 5.92 ± 0.01 | 5.01 ± 0.16 | 12.78 ± 0.55 |
2 | >100 | 39.77 ± 2.15 | 38.99 ± 2.42 | 27.13 ± 6.51 | 18.97 ± 3.47 | 51.68 ± 0.66 | 36.31 ± 3.75 | 31.73 ± 2.11 |
Cisplatin b | 9.55 ± 0.46 | 16.32 ± 1.37 | 12.37 ± 1.53 | 9.45 ± 2.05 | 28.15 ± 1.67 | 19.4 ± 0.58 | 9.59 ± 0.48 | 15.87 ± 0.36 |
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Yang, Q.-Y.; Cao, Q.-Q.; Qin, Q.-P.; Deng, C.-X.; Liang, H.; Chen, Z.-F. Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol. Int. J. Mol. Sci. 2018, 19, 1874. https://doi.org/10.3390/ijms19071874
Yang Q-Y, Cao Q-Q, Qin Q-P, Deng C-X, Liang H, Chen Z-F. Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol. International Journal of Molecular Sciences. 2018; 19(7):1874. https://doi.org/10.3390/ijms19071874
Chicago/Turabian StyleYang, Qi-Yuan, Qian-Qian Cao, Qi-Pin Qin, Cai-Xing Deng, Hong Liang, and Zhen-Feng Chen. 2018. "Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol" International Journal of Molecular Sciences 19, no. 7: 1874. https://doi.org/10.3390/ijms19071874