Ion Channels and Thermosensitivity: TRP, TREK, or Both?
Abstract
:1. Introduction
2. TREK Channels
2.1. TREK1
2.2. TREK2
2.3. TRAAK
2.4. Molecular Origin of Thermosensitivity
3. TRP Channels
3.1. Heat-Sensitive TRP Channels
3.2. Cold-Sensitive TRP Channels
3.3. Molecular Origin of Thermosensitivity
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
COS | Cell line derived from kidney |
DRG | Dorsal root ganglion |
HEK | Human embryonic kidney |
K2P | Two-pore domain potassium channels |
NG | Nodose ganglion |
NS | Nervous system |
PKA | Protein kinase A |
TG | Trigeminal ganglion |
TRAAK | TWIK-related arachidonic acid-activated potassium channel |
TREK | TWIK-related potassium channel |
RMP | Resting membrane potential |
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Lamas, J.A.; Rueda-Ruzafa, L.; Herrera-Pérez, S. Ion Channels and Thermosensitivity: TRP, TREK, or Both? Int. J. Mol. Sci. 2019, 20, 2371. https://doi.org/10.3390/ijms20102371
Lamas JA, Rueda-Ruzafa L, Herrera-Pérez S. Ion Channels and Thermosensitivity: TRP, TREK, or Both? International Journal of Molecular Sciences. 2019; 20(10):2371. https://doi.org/10.3390/ijms20102371
Chicago/Turabian StyleLamas, J. Antonio, Lola Rueda-Ruzafa, and Salvador Herrera-Pérez. 2019. "Ion Channels and Thermosensitivity: TRP, TREK, or Both?" International Journal of Molecular Sciences 20, no. 10: 2371. https://doi.org/10.3390/ijms20102371