ILC2 Activation by Protozoan Commensal Microbes
Abstract
:1. The ILC Lineage
1.1. The Family of Innate Lymphoid Cells
1.2. Transcriptional Specification of the ILC2 Lineage
1.3. ILC2 Heterogeneity Across Tissues
2. Activation and Inhibition of ILC2
2.1. Cytokine Receptor Profiles
2.2. Activating and Inhibiting Surface Receptors on ILC2
2.2.1. GITR (TNFRSF18)
2.2.2. CRTH2
2.2.3. ICOS/ICOSL (CD278)
2.2.4. KLRG1
2.2.5. PD-1 (CD279)
2.2.6. NKp30 (NCR3/CD337)
2.3. Lipid-Driven Modulation of ILC2
2.3.1. Leukotrienes
2.3.2. Prostaglandins
2.3.3. Lipoxins
2.4. Regulation of ILC2 by Metabolites
2.5. Neuronal and Hormonal Modulation of ILC2
2.6. Hormone-Mediated Sex Differences in ILC2 Function
2.7. Control of ILC2 function by MicroRNA
3. ILC2-Tissue Crosstalk
4. Protozoan Commensals as Regulator of ILC2 Activity
- Are there several pools of ILC2 precursors?
- What is the contribution of postnatal and adult ILC2 to tissue homeostasis and host defense?
- Which are ILC2 specific tissue niches?
- What is the role of Tuft cell subsets across tissues in regulating ILC2 activity?
- Exploring the potential of ILC2s in immunotherapy during host immunity.
- Identifying lineage determining transcription factors in human ILC2 for the use in iPSC technology.
- Developing ILC2-specific Cre/reporter lines for faithful tracking of ILC2 subset or ILC2 at distinct developmental stages.
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Burrows, K.; Ngai, L.; Wong, F.; Won, D.; Mortha, A. ILC2 Activation by Protozoan Commensal Microbes. Int. J. Mol. Sci. 2019, 20, 4865. https://doi.org/10.3390/ijms20194865
Burrows K, Ngai L, Wong F, Won D, Mortha A. ILC2 Activation by Protozoan Commensal Microbes. International Journal of Molecular Sciences. 2019; 20(19):4865. https://doi.org/10.3390/ijms20194865
Chicago/Turabian StyleBurrows, Kyle, Louis Ngai, Flora Wong, David Won, and Arthur Mortha. 2019. "ILC2 Activation by Protozoan Commensal Microbes" International Journal of Molecular Sciences 20, no. 19: 4865. https://doi.org/10.3390/ijms20194865
APA StyleBurrows, K., Ngai, L., Wong, F., Won, D., & Mortha, A. (2019). ILC2 Activation by Protozoan Commensal Microbes. International Journal of Molecular Sciences, 20(19), 4865. https://doi.org/10.3390/ijms20194865