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Volume 20
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Review

Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering

by
Min-Ah Koo
1,2,
Mi Hee Lee
1 and
Jong-Chul Park
1,2,*
1
Department of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Korea
2
Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(22), 5656; https://doi.org/10.3390/ijms20225656
Submission received: 11 October 2019 / Revised: 6 November 2019 / Accepted: 8 November 2019 / Published: 12 November 2019
(This article belongs to the Special Issue Potential Application of Cell Sheets, for Tissue Engineering and Repairing Tissue)
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Abstract

Cell sheet engineering has evolved rapidly in recent years as a new approach for cell-based therapy. Cell sheet harvest technology is important for producing viable, transplantable cell sheets and applying them to tissue engineering. To date, most cell sheet studies use thermo-responsive systems to detach cell sheets. However, other approaches have been reported. This review provides the progress in cell sheet detachment techniques, particularly reactive oxygen species (ROS)-responsive strategies. Therefore, we present a comprehensive introduction to ROS, their application in regenerative medicine, and considerations on how to use ROS in cell detachment. The review also discusses current limitations and challenges for clarifying the mechanism of the ROS-responsive cell sheet detachment.
Keywords: cell sheet; cell detachment; reactive oxygen species cell sheet; cell detachment; reactive oxygen species

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MDPI and ACS Style

Koo, M.-A.; Lee, M.H.; Park, J.-C. Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering. Int. J. Mol. Sci. 2019, 20, 5656. https://doi.org/10.3390/ijms20225656

AMA Style

Koo M-A, Lee MH, Park J-C. Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering. International Journal of Molecular Sciences. 2019; 20(22):5656. https://doi.org/10.3390/ijms20225656

Chicago/Turabian Style

Koo, Min-Ah, Mi Hee Lee, and Jong-Chul Park. 2019. "Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering" International Journal of Molecular Sciences 20, no. 22: 5656. https://doi.org/10.3390/ijms20225656

APA Style

Koo, M.-A., Lee, M. H., & Park, J.-C. (2019). Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering. International Journal of Molecular Sciences, 20(22), 5656. https://doi.org/10.3390/ijms20225656

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