The Crosstalk Between Cell Adhesion and Cancer Metabolism
Abstract
:1. Introduction
2. Metabolic Rewiring During Cancer Progression
3. EMT, Cancer Stemness, and Metabolic Plasticity
4. Biomechanics, Tissue Stiffness, and Energetic Needs Regulate Cancer Cell Metabolism
5. Alterations in Cell-Matrix Adhesion Modulates Metabolic Pathways
6. Modifications in Cell–Cell Adhesion Affects Cancer Metabolism
6.1. Epithelial-Cadherin (E-Cadherin)
6.2. Placental Cadherin (P-Cadherin)
6.3. Fat (ft)-like Cadherin
7. Concluding Remarks
Author Contributions
Acknowledgments
Conflicts of Interest
Abbreviations
ACC1/ACC2 | acetyl-CoA carboxylase 1/2 |
ADP | Adenosine diphosphate |
AKT | Protein kinase B (PKB) |
ALDH | Aldehyde Dehydrogenase |
AMPK | AMP-activated protein kinase |
ATP | Adenosine triphosphate |
Bad | BCL2 Associated Agonist of Cell Death |
BCSC | Breast Cancer Stem Cells |
BNIP3 | BCL2 Interacting Protein 3 |
CAIX | Carbonic Anhydrase IX |
CD147 | Cluster of Differentiation 147 |
E-cadherin | Epithelial cadherin |
ECM | Extracellular Matrix |
EGF | Epidermal Growth Factor |
EGFR | Epidermal Growth Factor Receptor |
EMT | Epithelial Mesenchymal Transition |
ERK | Extracellular-signal-Regulated Kinase |
ETC | Electron Transport Chain |
FAK | Focal Adhesion Kinase |
FAO | Fatty Acid Oxidation |
FAS | Fatty Acid Synthesis |
FBP1 | Fructose-1,6-bisphosphatase 1 |
Ft | Fat |
Ftmito | Mitochondrial Fat Soluble fragment |
GLUT1/4 | Glucose Transporter ¼ |
GTP | Guanosine-5′-triphosphate |
HER2 | Human Epidermal Growth Factor Receptor 2 |
HIF-1α | Hipoxia Inducible Factor-1α |
HK2 | Hexokinase 2 |
LKB1 | Large Kinase B1 |
MAPK | Mitogen-Activated Protein Kinase |
MCT | Monocarboxylate Transporters |
MET | Mesenchymal Epithelial Transition |
MMP | Matrix Metalloproteinase |
mTOR | mammalian target of rapamycin |
MYC | Myelocytomatosis oncogene |
NAC | N-acetyl Cysteine |
NADPH | Nicotinamide Adenine Dinucleotide Phosphate |
Ndufv2 | NADH dehydrogenase ubiquinone flavo-protein 2 |
NF-κB | Nuclear Factor Kappa B |
OXPHOS | Oxidative Phosphorylation |
P-cadherin | Placental-cadherin |
PDK4 | Pyruvate Dehydrogenase kinase 4 |
PFK | Phosphofructokinase |
PGC-1α | PPARg co-activator 1α |
PGK1 | Phosphoglycerate kinase 1 |
PI(3)K | Phosphoinositide 3-kinase |
PKM2 | Pyruvate Kinase isozyme Muscle 1 |
PPARγ | Peroxisome proliferator-activated receptor gamma |
PPP | Pentose Phosphate Pathway |
Rac | Ras-related C3 botulinum toxin substrate 1 |
REDD1 | Regulated in Development and DNA Damage Response 1 |
ROS | Reactive Oxygen Species |
SFK | Src family Kinase |
SMC | smooth muscle cell |
sP-cad | soluble P-cadherin fragment |
STRAD | STe20 Related ADapter |
TSG | Tumor Suppressor Gene |
VEGF | Vascular Endothelial Growth Factor |
YAP | Yes-associated protein |
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Sousa, B.; Pereira, J.; Paredes, J. The Crosstalk Between Cell Adhesion and Cancer Metabolism. Int. J. Mol. Sci. 2019, 20, 1933. https://doi.org/10.3390/ijms20081933
Sousa B, Pereira J, Paredes J. The Crosstalk Between Cell Adhesion and Cancer Metabolism. International Journal of Molecular Sciences. 2019; 20(8):1933. https://doi.org/10.3390/ijms20081933
Chicago/Turabian StyleSousa, Bárbara, Joana Pereira, and Joana Paredes. 2019. "The Crosstalk Between Cell Adhesion and Cancer Metabolism" International Journal of Molecular Sciences 20, no. 8: 1933. https://doi.org/10.3390/ijms20081933