P2X7 Receptor at the Crossroads of T Cell Fate

Rivas-Yáñez, Elizabeth; Barrera-Avalos, Carlos; Parra-Tello, Brian; Briceño, Pedro; Rosemblatt, Mariana V.; Saavedra-Almarza, Juan; Rosemblatt, Mario; Acuña-Castillo, Claudio; Bono, María Rosa; Sauma, Daniela

doi:10.3390/ijms21144937

Open AccessReview

P2X7 Receptor at the Crossroads of T Cell Fate

by

Elizabeth Rivas-Yáñez

¹,

Carlos Barrera-Avalos

²

,

Brian Parra-Tello

¹,

Pedro Briceño

¹,

Mariana V. Rosemblatt

^1,3

,

Juan Saavedra-Almarza

¹

,

Mario Rosemblatt

^1,3,4,

Claudio Acuña-Castillo

^5,*

,

María Rosa Bono

^1,* and

Daniela Sauma

^1,*

¹

Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, Chile

²

Departamento de Biología, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 9160000, Chile

³

Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago 7510157, Chile

⁴

Fundación Ciencia & Vida, Santiago 7780272, Chile

⁵

Centro de Biotecnología Acuícola, Universidad de Santiago de Chile, Santiago 9160000, Chile

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2020, 21(14), 4937; https://doi.org/10.3390/ijms21144937

Submission received: 4 June 2020 / Revised: 26 June 2020 / Accepted: 7 July 2020 / Published: 13 July 2020

(This article belongs to the Special Issue Purinergic P2 Receptors: Structure and Function)

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Abstract

The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular NAD. Upon activation, this receptor induces several responses, including the influx of calcium and sodium ions, phosphatidylserine externalization, the formation of a non-selective membrane pore, and ultimately cell death. P2X7 receptor activation depends on the availability of extracellular nucleotides, whose concentrations are regulated by the action of extracellular nucleotidases such as CD39 and CD38. The P2X7 receptor has been extensively studied in the context of the immune response, and it has been reported to be involved in inflammasome activation, cytokine production, and the migration of different innate immune cells in response to ATP. In adaptive immune responses, the P2X7 receptor has been linked to T cell activation, differentiation, and apoptosis induction. In this review, we will discuss the evidence of the role of the P2X7 receptor on T cell differentiation and in the control of T cell responses in inflammatory conditions.

Keywords: P2X7 receptor; ectonucleotidases; T cell

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MDPI and ACS Style

Rivas-Yáñez, E.; Barrera-Avalos, C.; Parra-Tello, B.; Briceño, P.; Rosemblatt, M.V.; Saavedra-Almarza, J.; Rosemblatt, M.; Acuña-Castillo, C.; Bono, M.R.; Sauma, D. P2X7 Receptor at the Crossroads of T Cell Fate. Int. J. Mol. Sci. 2020, 21, 4937. https://doi.org/10.3390/ijms21144937

AMA Style

Rivas-Yáñez E, Barrera-Avalos C, Parra-Tello B, Briceño P, Rosemblatt MV, Saavedra-Almarza J, Rosemblatt M, Acuña-Castillo C, Bono MR, Sauma D. P2X7 Receptor at the Crossroads of T Cell Fate. International Journal of Molecular Sciences. 2020; 21(14):4937. https://doi.org/10.3390/ijms21144937

Chicago/Turabian Style

Rivas-Yáñez, Elizabeth, Carlos Barrera-Avalos, Brian Parra-Tello, Pedro Briceño, Mariana V. Rosemblatt, Juan Saavedra-Almarza, Mario Rosemblatt, Claudio Acuña-Castillo, María Rosa Bono, and Daniela Sauma. 2020. "P2X7 Receptor at the Crossroads of T Cell Fate" International Journal of Molecular Sciences 21, no. 14: 4937. https://doi.org/10.3390/ijms21144937

APA Style

Rivas-Yáñez, E., Barrera-Avalos, C., Parra-Tello, B., Briceño, P., Rosemblatt, M. V., Saavedra-Almarza, J., Rosemblatt, M., Acuña-Castillo, C., Bono, M. R., & Sauma, D. (2020). P2X7 Receptor at the Crossroads of T Cell Fate. International Journal of Molecular Sciences, 21(14), 4937. https://doi.org/10.3390/ijms21144937

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P2X7 Receptor at the Crossroads of T Cell Fate

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