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Volume 21
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Article

miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients

by
Cora Rebecca Schindler
1,*,
Mathias Woschek
1,
Jan Tilmann Vollrath
1,
Kerstin Kontradowitz
1,
Thomas Lustenberger
1,2,
Philipp Störmann
1,
Ingo Marzi
1 and
Dirk Henrich
1
1
Department of Trauma-, Hand and Reconstructive Surgery, University Hospital Frankfurt, 60596 Frankfurt, Germany
2
Department of Traumatology, Cantonal Hospital Aarau, Tellstrasse, 5001 Aarau, Switzerland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(15), 5381; https://doi.org/10.3390/ijms21155381
Submission received: 14 June 2020 / Revised: 24 July 2020 / Accepted: 27 July 2020 / Published: 29 July 2020
(This article belongs to the Section Molecular Biology)
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Abstract

Background: Predictive biomarkers in biofluids are the most commonly used diagnostic method, but established markers in trauma diagnostics lack accuracy. This study investigates promising microRNAs (miRNA) released from affected tissue after severe trauma that have predictive values for the effects of the injury. Methods: A retrospective analysis of prospectively collected data and blood samples of n = 33 trauma patients (ISS ≥ 16) is provided. Levels of miR-9-5p, -124-3p, -142-3p, -219a-5p, -338-3p and -423-3p in severely injured patients (PT) without traumatic brain injury (TBI) or with severe TBI (PT + TBI) and patients with isolated TBI (isTBI) were measured within 6 h after trauma. Results: The highest miR-423-3p expression was detected in patients with severe isTBI, followed by patients with PT + TBI, and lowest levels were found in PT patients without TBI (2−∆∆Ct, p = 0.009). A positive correlation between miR-423-3p level and increasing AIShead (p = 0.001) and risk of mortality (RISC II, p = 0.062) in trauma patients (n = 33) was found. ROC analysis of miR-423-3p levels revealed them as statistically significant to predict the severity of brain injury in trauma patients (p = 0.006). miR-124-3p was only found in patients with severe TBI, miR-338-3p was shown in all trauma groups. miR-9-5p, miR-142-3p and miR-219a-5p could not be detected in any of the four groups. Conclusion: miR-423-3p expression is significantly elevated after isolated traumatic brain injury and predictable for severe TBI in the first hours after trauma. miR-423-3p could represent a promising new biomarker to identify severe isolated TBI.
Keywords: miR-142-3p; miRNA; serum; plasma; SNORD95; traumatic brain injury (TBI); polytrauma; Injury Severity Score (ISS) miR-142-3p; miRNA; serum; plasma; SNORD95; traumatic brain injury (TBI); polytrauma; Injury Severity Score (ISS)

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MDPI and ACS Style

Schindler, C.R.; Woschek, M.; Vollrath, J.T.; Kontradowitz, K.; Lustenberger, T.; Störmann, P.; Marzi, I.; Henrich, D. miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients. Int. J. Mol. Sci. 2020, 21, 5381. https://doi.org/10.3390/ijms21155381

AMA Style

Schindler CR, Woschek M, Vollrath JT, Kontradowitz K, Lustenberger T, Störmann P, Marzi I, Henrich D. miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients. International Journal of Molecular Sciences. 2020; 21(15):5381. https://doi.org/10.3390/ijms21155381

Chicago/Turabian Style

Schindler, Cora Rebecca, Mathias Woschek, Jan Tilmann Vollrath, Kerstin Kontradowitz, Thomas Lustenberger, Philipp Störmann, Ingo Marzi, and Dirk Henrich. 2020. "miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients" International Journal of Molecular Sciences 21, no. 15: 5381. https://doi.org/10.3390/ijms21155381

APA Style

Schindler, C. R., Woschek, M., Vollrath, J. T., Kontradowitz, K., Lustenberger, T., Störmann, P., Marzi, I., & Henrich, D. (2020). miR-142-3p Expression Is Predictive for Severe Traumatic Brain Injury (TBI) in Trauma Patients. International Journal of Molecular Sciences, 21(15), 5381. https://doi.org/10.3390/ijms21155381

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