Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions
Abstract
:1. Overnutrition and Altered Energy Homeostasis
2. Mitochondria Dysfunctions, Oxidative Stress and Inflammation
3. Interplay between Obesity and Aging: Inflammation and Neuroinflammation
4. Overnutrition-Dependent Neuroinflammation and Hypothalamic AMPK Activation
5. Overnutrition and Synaptic Plasticity
5.1. Overnutrition and BDNF
5.2. Overnutrition and Brain Mitochondrial Dysfunctions
5.2.1. Alzheimer’s Disease
5.2.2. Parkinson’s Disease
5.2.3. Bipolar Disorders and Schizophrenia
5.3. Overnutrition and Serotonin Signaling
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
HFD | High fat diet |
ROS | Reactive oxygen species |
AMP | Adenosine monophosphate |
BDNF | Brain derived neurotrophic factor |
ER | Endoplasmic reticulum |
IR | Insulin resistance |
FFA | Free fatty acids |
TLR4 | Toll-like receptor 4 |
NF-κB | Nuclear factor kappa-light-chain-enhancer of activated B cells |
TNFα | Tumour necrosis factor-α |
IL-6 | Interleukin-6 |
AMPK | Adenosine monophosphate activated protein kinase |
ACC | Acetyl-CoA carboxylase |
CPT | Carnitine palmitoyl-transferase |
CNS | Central nervous system |
IKK | IkB kinase |
ncRNA | Non-coding RNA |
POMC | Pro-opiomelanocortin |
PFC | Prefrontal cortex |
GABA | γ-aminobutyric acid |
miRNAs | microRNAs |
LTP | Long-term potentiation |
IEGs | Immediate early genes |
AD | Alzheimer’s disease |
APP | Amyloid precursor protein |
mTOR | Mammalian target of rapamycin |
5-HT | Serotonin |
UCP1 | Uncoupling protein 1 |
PGC | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha |
PINK1 | PTEN-induced putative kinase 1 |
DHA | Docosahexaenoic acid |
PUFAs | polyunsaturated fatty acids |
PD | Parkinson’s disease |
NPY/AgRP | neuropeptide Y/agouti-related peptide |
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Crispino, M.; Trinchese, G.; Penna, E.; Cimmino, F.; Catapano, A.; Villano, I.; Perrone-Capano, C.; Mollica, M.P. Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions. Int. J. Mol. Sci. 2020, 21, 5964. https://doi.org/10.3390/ijms21175964
Crispino M, Trinchese G, Penna E, Cimmino F, Catapano A, Villano I, Perrone-Capano C, Mollica MP. Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions. International Journal of Molecular Sciences. 2020; 21(17):5964. https://doi.org/10.3390/ijms21175964
Chicago/Turabian StyleCrispino, Marianna, Giovanna Trinchese, Eduardo Penna, Fabiano Cimmino, Angela Catapano, Ines Villano, Carla Perrone-Capano, and Maria Pina Mollica. 2020. "Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions" International Journal of Molecular Sciences 21, no. 17: 5964. https://doi.org/10.3390/ijms21175964