Next Article in Journal
Tofacitinib and Baricitinib Are Taken up by Different Uptake Mechanisms Determining the Efficacy of Both Drugs in RA
Next Article in Special Issue
Dietary Salt Administration Decreases Enterotoxigenic Bacteroides fragilis (ETBF)-Promoted Tumorigenesis via Inhibition of Colonic Inflammation
Previous Article in Journal
Superparamagnetic Iron Oxide Nanoparticles and Essential Oils: A New Tool for Biological Applications
Previous Article in Special Issue
Cannabinoids and Prostate Cancer: A Systematic Review of Animal Studies
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 18
10.3390/ijms21186635
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies

by
Monica Benvenuto
1,2,
Loredana Albonici
2,
Chiara Focaccetti
2,3,
Sara Ciuffa
2,
Sara Fazi
4,
Loredana Cifaldi
2,5,
Martino Tony Miele
6,
Fernando De Maio
2,
Ilaria Tresoldi
2,
Vittorio Manzari
2,
Andrea Modesti
2,
Laura Masuelli
4,† and
Roberto Bei
2,*,†
1
Saint Camillus International University of Health and Medical Sciences, Via di Sant’Alessandro 8, 00131 Rome, Italy
2
Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
3
Department of Human Science and Promotion of the Quality of Life, San Raffaele University Rome, Via di Val Cannuta 247, 00166 Rome, Italy
4
Department of Experimental Medicine, University of Rome “Sapienza”, Viale Regina Elena 324, 00161 Rome, Italy
5
Academic Department of Pediatrics (DPUO), Ospedale Pediatrico Bambino Gesù, IRCCS, Piazza Sant’Onofrio 4, 00165 Rome, Italy
6
Department of Experimental Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(18), 6635; https://doi.org/10.3390/ijms21186635
Submission received: 7 August 2020 / Revised: 7 September 2020 / Accepted: 8 September 2020 / Published: 10 September 2020
(This article belongs to the Special Issue The Effect of Dietary Factors on Cancer 2.0)
Browse Figures
Versions Notes

Abstract

One of the hallmarks of cellular transformation is the altered mechanism of cell death. There are three main types of cell death, characterized by different morphological and biochemical features, namely apoptosis (type I), autophagic cell death (type II) and necrosis (type III). Autophagy, or self-eating, is a tightly regulated process involved in stress responses, and it is a lysosomal degradation process. The role of autophagy in cancer is controversial and has been associated with both the induction and the inhibition of tumor growth. Autophagy can exert tumor suppression through the degradation of oncogenic proteins, suppression of inflammation, chronic tissue damage and ultimately by preventing mutations and genetic instability. On the other hand, tumor cells activate autophagy for survival in cellular stress conditions. Thus, autophagy modulation could represent a promising therapeutic strategy for cancer. Several studies have shown that polyphenols, natural compounds found in foods and beverages of plant origin, can efficiently modulate autophagy in several types of cancer. In this review, we summarize the current knowledge on the effects of polyphenols on autophagy, highlighting the conceptual benefits or drawbacks and subtle cell-specific effects of polyphenols for envisioning future therapies employing polyphenols as chemoadjuvants.
Keywords: polyphenols; natural compound; autophagy; cancer; cell death; cytoprotective polyphenols; natural compound; autophagy; cancer; cell death; cytoprotective

Share and Cite

MDPI and ACS Style

Benvenuto, M.; Albonici, L.; Focaccetti, C.; Ciuffa, S.; Fazi, S.; Cifaldi, L.; Miele, M.T.; De Maio, F.; Tresoldi, I.; Manzari, V.; et al. Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies. Int. J. Mol. Sci. 2020, 21, 6635. https://doi.org/10.3390/ijms21186635

AMA Style

Benvenuto M, Albonici L, Focaccetti C, Ciuffa S, Fazi S, Cifaldi L, Miele MT, De Maio F, Tresoldi I, Manzari V, et al. Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies. International Journal of Molecular Sciences. 2020; 21(18):6635. https://doi.org/10.3390/ijms21186635

Chicago/Turabian Style

Benvenuto, Monica, Loredana Albonici, Chiara Focaccetti, Sara Ciuffa, Sara Fazi, Loredana Cifaldi, Martino Tony Miele, Fernando De Maio, Ilaria Tresoldi, Vittorio Manzari, and et al. 2020. "Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies" International Journal of Molecular Sciences 21, no. 18: 6635. https://doi.org/10.3390/ijms21186635

APA Style

Benvenuto, M., Albonici, L., Focaccetti, C., Ciuffa, S., Fazi, S., Cifaldi, L., Miele, M. T., De Maio, F., Tresoldi, I., Manzari, V., Modesti, A., Masuelli, L., & Bei, R. (2020). Polyphenol-Mediated Autophagy in Cancer: Evidence of In Vitro and In Vivo Studies. International Journal of Molecular Sciences, 21(18), 6635. https://doi.org/10.3390/ijms21186635

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop