Next Article in Journal
Endothelial Damage in Acute Respiratory Distress Syndrome
Next Article in Special Issue
Regulator of G Protein Signalling 4 (RGS4) as a Novel Target for the Treatment of Sensorineural Hearing Loss
Previous Article in Journal
Sphingomyelin Deacylase, the Enzyme Involved in the Pathogenesis of Atopic Dermatitis, Is Identical to the β-Subunit of Acid Ceramidase
Previous Article in Special Issue
Hyperbaric Oxygenation as Adjunctive Therapy in the Treatment of Sudden Sensorineural Hearing Loss
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 22
10.3390/ijms21228792
Review Report
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

Printed Edition

A printed edition of this Special Issue is available at MDPI Books....
share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Changes in microRNA Expression in the Cochlear Nucleus and Inferior Colliculus after Acute Noise-Induced Hearing Loss

Int. J. Mol. Sci. 2020, 21(22), 8792; https://doi.org/10.3390/ijms21228792
by Sohyeon Park 1,2, Seung Hee Han 2, Byeong-Gon Kim 2,3, Myung-Whan Suh 2, Jun Ho Lee 2,3, Seung Ha Oh 2,3 and Moo Kyun Park 2,3,4,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(22), 8792; https://doi.org/10.3390/ijms21228792
Submission received: 27 October 2020 / Revised: 18 November 2020 / Accepted: 19 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics)

Round 1

Reviewer 1 Report

In general it is very interesting manuscript . choice of Journal also is in my opinion appropriate. In introduction there is need for improvement and more explanation from audiological point of view - PTS and TTS terms should be applied in translation for humans. Results are prepared very nice. Scientific loudness is good. In conclusion there is need to more precise show impacts for clinical practice. How it influence to some human studies with NIHL 

Author Response

Point 1:  In introduction there is need for improvement and more explanation from audiological point of view - PTS and TTS terms should be applied in translation for humans. 

Response 1: In the second and third paragraph of the introduction, I added  a part  that explains the definition and the meaning of TTS and PTS and how it affects the auditory processing and what kind of other diseases they cause.

Point 2: In conclusion there is need to more precise show impacts for clinical practice. How it influence to some human studies with NIHL.

Response 2:By adding an example of clinical trials of miRNAs at the end of the fifth paragraph of the introduction, I also rewrote the conclusion explaining about how miRNAs can be used in the clinical field. For example, a miRNAs detection kit can be used as an early diagnostic tool and also miRNAs can be used as gene therapeutics for NIHL patients.

 

Author Response File: Author Response.docx

Reviewer 2 Report

REVIEW

In an article Sohyeon Park, Seung Hee Han, Byeong-Gon Kim, Myung-Whan Suh, Jun Ho Lee, Seung Ha Oh and Moo Kyun Park “MicroRNA Expression Changes in Cochlear Nucleus and Inferior Colliculus after Acute Noise-induced Hearing Loss”.

The article by Sohyeon Park and co-authors is investigated the role of microRNAs (miRNAs) in 21 the neural plasticity of the central auditory pathway after acute Acute Noise-induced Hearing Loss.

Major comment

No major comments, this is a perfect scientific work.

Minor comments

List of references not correctly framed, numbers are duplicated.

 

Author Response

Point 1:List of references not correctly framed, numbers are duplicated.

Response 1: Since I rewrote some parts of the introduction, some of the references were removed and some references were added. Therefore, the reference numbers were rearranged. I double checked for the duplicated references and edited. 

 

Author Response File: Author Response.docx

Back to TopTop