Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus
Abstract
:1. Venoms through History
2. Venom Evolution
3. Pore-Forming Proteins
4. Cnidarian’s Pore Forming Proteins
5. Sea Anemone Actinoporins
6. Sticholysins I, II, and III
7. The N-Terminal Stretch of the Different Sticholysins
8. The Nature of the Sticholysins’ Functional Pore
9. Synergy among the Different Sticholysins
10. The Influence of Cholesterol
11. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
BAK | Bcl-2 homologous antagonist/killer |
BAX | Bcl-2 associated X protein |
CfTX | Chinorex fleckeri toxin |
Chol | cholesterol |
CTL | cholestatrienol |
DOPC | dioleyl-phosphatidylcholine |
Eqt | equinatoxin |
Fra | fragaceatoxin |
FRET | fluorescence resonance energy transfer |
MACPF | membrane attack complex/perforin family |
PFP | pore-forming protein |
PLA2 | phospholipase A2 |
POC | phosphorylcholine |
POPE-NBD | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(7-nitro-2-1,3-benzoxadiazol-4-yl) |
R6G | Rhodamine 6G |
RHA | relative hemolytic activity |
RMB | relative membrane binding |
SM | sphingomyelin |
Stn | sticholysin |
wt | wild-type |
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Rivera-de-Torre, E.; Palacios-Ortega, J.; Slotte, J.P.; Gavilanes, J.G.; Martínez-del-Pozo, Á.; García-Linares, S. Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus. Int. J. Mol. Sci. 2020, 21, 8915. https://doi.org/10.3390/ijms21238915
Rivera-de-Torre E, Palacios-Ortega J, Slotte JP, Gavilanes JG, Martínez-del-Pozo Á, García-Linares S. Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus. International Journal of Molecular Sciences. 2020; 21(23):8915. https://doi.org/10.3390/ijms21238915
Chicago/Turabian StyleRivera-de-Torre, Esperanza, Juan Palacios-Ortega, J. Peter Slotte, José G. Gavilanes, Álvaro Martínez-del-Pozo, and Sara García-Linares. 2020. "Functional and Structural Variation among Sticholysins, Pore-Forming Proteins from the Sea Anemone Stichodactyla helianthus" International Journal of Molecular Sciences 21, no. 23: 8915. https://doi.org/10.3390/ijms21238915