IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target
Abstract
:1. Introduction
2. Acute Kidney Injury (AKI)
3. Chronic Kidney Disease (CKD)
4. Diabetic Nephropathy
5. Inflammation and Kidney Disease
6. MCP-1(CCL2)/CCR2
7. IL-8/CXCL8
8. TNF-α
9. IL-1β
10. IL-6
11. Transforming Growth Factor-β (TGF-β)
12. Hypoxia in Kidney Disease
13. IL-20
14. IL-20 in AKI
15. IL-20 in CKD
16. IL-20 in DN
17. IL-20 Antibody Therapy in Kidney Disease
18. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Organ | Diseases | Target Cells | Role | Reference |
---|---|---|---|---|
Brain | Ischemic Stroke | Glia-like cells | ↑ Inflammation ↑ Ischemic infarction | [162] |
Mouth | Oral Cancer | Oral carcinoma cells | ↑ Tumor progression ↑ Inflammation | [157] |
Airway | Asthma | Lung epithelial cells | ↑ Lung fibrosis | [160] |
Arterial | Atherosclerosis | Endothelial cells | ↑ Inflammation ↑ Angiogenesis ↑ Atherosclerosis | [158] |
Liver | Hepatocellular Carcinoma (HCC) | Liver cancer cells | ↑ Tumor progression | [163] |
Liver Injury | Hepatocytes | ↑ Liver fibrosis ↑ Inflammation | [164] | |
Pancreas | Type 2 Diabetes | Pancreatic islets | ↑ Inflammation | [165] |
Kidney | Hgcl2-Induced AKI | Proximal tubular epithelial cells | ↑ Inflammation ↑ Renal fibrosis ↑ Cell death | [161] |
5/6 nephrectomy-Induced CKD | Tubular epithelial cells Interstitial fibroblasts | ↑ Renal fibrosis | [166] | |
STZ-induced DN | Podocytes | ↑ Inflammation ↑ Fibrosis ↓ Renal function | [167] | |
Lupus Nephritis | Mesangial cells | ↑ Inflammation | [168] | |
Skin | Psoriasis | Keratinocytes | ↑ Cell proliferation | [169,170] |
Bone | RA | Synovial fibroblasts Osteoclasts Osteoblasts Chondrocytes | ↑ Inflammation | [155] |
Spondyloarthritis | Synovial fluid monocytes Synovial fibroblasts Osteoblasts | ↑ Inflammation ↑ Osteoblastogenesis | [171] | |
Osteoporosis | Osteoclasts Osteoblasts | ↑ Osteoclastogenesis ↓ Osteoblastogenesis | [172] | |
Osteoarthritis | Synovial fibroblasts Chondrocytes | ↑ Inflammation ↓ Chondrogenesis ↑ Osteoblastogenesis | [156] | |
Intervertebral Disc (IVD) Herniation | Disc Cells | ↑ Inflammation | [173] |
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Lin, T.-Y.; Hsu, Y.-H. IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target. Int. J. Mol. Sci. 2020, 21, 1009. https://doi.org/10.3390/ijms21031009
Lin T-Y, Hsu Y-H. IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target. International Journal of Molecular Sciences. 2020; 21(3):1009. https://doi.org/10.3390/ijms21031009
Chicago/Turabian StyleLin, Tian-Yu, and Yu-Hsiang Hsu. 2020. "IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target" International Journal of Molecular Sciences 21, no. 3: 1009. https://doi.org/10.3390/ijms21031009