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Review

The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis

by
Salvador C. Herrera
1,* and
Erika A. Bach
2,3,*
1
Centro Andaluz de Biología del Desarrollo, CSIC/Universidad Pablo de Olavide/JA, Carretera de Utrera km 1, 41018 Sevilla, Spain
2
Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA
3
Helen L. and Martin S. Kimmel Center for Stem Cell Biology, New York University Grossman School of Medicine, New York, NY 10016, USA
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(11), 5519; https://doi.org/10.3390/ijms22115519
Submission received: 16 April 2021 / Revised: 20 May 2021 / Accepted: 21 May 2021 / Published: 24 May 2021
(This article belongs to the Special Issue Function and Mechanisms of JNK Pathway)
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Abstract

The Jun N-terminal kinase (JNK) pathway is an evolutionary conserved kinase cascade best known for its roles during stress-induced apoptosis and tumor progression. Recent findings, however, have identified new roles for this pleiotropic pathway in stem cells during regenerative responses and in cellular plasticity. Here, we provide an overview of recent findings about the new roles of JNK signaling in stem cell biology using two well-established Drosophila models: the testis and the intestine. We highlight the pathway’s roles in processes such as proliferation, death, self-renewal and reprogramming, and discuss the known parallels between flies and mammals.
Keywords: Drosophila; niche; germline stem cells; somatic stem cells; testis; intestine; intestinal stem cells; enterocytes; proliferation; cell death; differentiation; inflammation; regeneration; cellular plasticity; cell reprogramming Drosophila; niche; germline stem cells; somatic stem cells; testis; intestine; intestinal stem cells; enterocytes; proliferation; cell death; differentiation; inflammation; regeneration; cellular plasticity; cell reprogramming

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MDPI and ACS Style

Herrera, S.C.; Bach, E.A. The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis. Int. J. Mol. Sci. 2021, 22, 5519. https://doi.org/10.3390/ijms22115519

AMA Style

Herrera SC, Bach EA. The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis. International Journal of Molecular Sciences. 2021; 22(11):5519. https://doi.org/10.3390/ijms22115519

Chicago/Turabian Style

Herrera, Salvador C., and Erika A. Bach. 2021. "The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis" International Journal of Molecular Sciences 22, no. 11: 5519. https://doi.org/10.3390/ijms22115519

APA Style

Herrera, S. C., & Bach, E. A. (2021). The Emerging Roles of JNK Signaling in Drosophila Stem Cell Homeostasis. International Journal of Molecular Sciences, 22(11), 5519. https://doi.org/10.3390/ijms22115519

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