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Review

Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy

by
Edyta Dziadkowiak
1,*,
Justyna Chojdak-Łukasiewicz
1,
Piotr Olejniczak
2 and
Bogusław Paradowski
1
1
Department of Neurology, Wroclaw Medical University, 50-367 Wroclaw, Poland
2
Department of Neurology, Louisiana State University Health Sciences Center in New Orleans, 1542 Tulane Avenue, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(14), 7370; https://doi.org/10.3390/ijms22147370
Submission received: 31 May 2021 / Revised: 20 June 2021 / Accepted: 2 July 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Brain Mechanisms of Sleep Related Disorders)

Abstract

The effects of epilepsy on sleep and the activating effects of sleep on seizures are well documented in the literature. To date, many sleep-related and awake-associated epilepsy syndromes have been described. The relationship between sleep and epilepsy has led to the recognition of polysomnographic testing as an important diagnostic tool in the diagnosis of epilepsy. The authors analyzed the available medical database in search of other markers that assess correlations between epilepsy and sleep. Studies pointing to microRNAs, whose abnormal expression may be common to epilepsy and sleep disorders, are promising. In recent years, the role of microRNAs in the pathogenesis of epilepsy and sleep disorders has been increasingly emphasized. MicroRNAs are a family of single-stranded, non-coding, endogenous regulatory molecules formed from double-stranded precursors. They are typically composed of 21–23 nucleotides, and their main role involves post-transcriptional downregulation of expression of numerous genes. Learning more about the role of microRNAs in the pathogenesis of sleep disorder epilepsy may result in its use as a biomarker in these disorders and application in therapy.
Keywords: sleep-related seizures; epilepsy; parasomnias; sleep disorders; microRNA sleep-related seizures; epilepsy; parasomnias; sleep disorders; microRNA

Share and Cite

MDPI and ACS Style

Dziadkowiak, E.; Chojdak-Łukasiewicz, J.; Olejniczak, P.; Paradowski, B. Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy. Int. J. Mol. Sci. 2021, 22, 7370. https://doi.org/10.3390/ijms22147370

AMA Style

Dziadkowiak E, Chojdak-Łukasiewicz J, Olejniczak P, Paradowski B. Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy. International Journal of Molecular Sciences. 2021; 22(14):7370. https://doi.org/10.3390/ijms22147370

Chicago/Turabian Style

Dziadkowiak, Edyta, Justyna Chojdak-Łukasiewicz, Piotr Olejniczak, and Bogusław Paradowski. 2021. "Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy" International Journal of Molecular Sciences 22, no. 14: 7370. https://doi.org/10.3390/ijms22147370

APA Style

Dziadkowiak, E., Chojdak-Łukasiewicz, J., Olejniczak, P., & Paradowski, B. (2021). Regulation of microRNA Expression in Sleep Disorders in Patients with Epilepsy. International Journal of Molecular Sciences, 22(14), 7370. https://doi.org/10.3390/ijms22147370

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