Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

Yoon, Seong Shoon; Yun, Jaesuk; Lee, Bong Hyo; Kim, Hee Young; Yang, Chae Ha

doi:10.3390/ijms22147519

Open AccessArticle

Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

by

Seong Shoon Yoon

^1,*

,

Jaesuk Yun

²,

Bong Hyo Lee

³,

Hee Young Kim

¹ and

Chae Ha Yang

^1,*

¹

Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea

²

College of Pharmacy and Medical Research Center, Chungbuk National University, Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju, Chungbuk 28160, Korea

³

Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea

^*

Authors to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(14), 7519; https://doi.org/10.3390/ijms22147519

Submission received: 28 June 2021 / Revised: 12 July 2021 / Accepted: 12 July 2021 / Published: 14 July 2021

(This article belongs to the Special Issue Neuro-Plastic Mechanisms of Pain and Addiction)

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Abstract

Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency–rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naïve rats.

Keywords: acupuncture; intracranial self-stimulation; rats; medial forebrain bundle; cocaine; brain reward function

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MDPI and ACS Style

Yoon, S.S.; Yun, J.; Lee, B.H.; Kim, H.Y.; Yang, C.H. Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats. Int. J. Mol. Sci. 2021, 22, 7519. https://doi.org/10.3390/ijms22147519

AMA Style

Yoon SS, Yun J, Lee BH, Kim HY, Yang CH. Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats. International Journal of Molecular Sciences. 2021; 22(14):7519. https://doi.org/10.3390/ijms22147519

Chicago/Turabian Style

Yoon, Seong Shoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, and Chae Ha Yang. 2021. "Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats" International Journal of Molecular Sciences 22, no. 14: 7519. https://doi.org/10.3390/ijms22147519

APA Style

Yoon, S. S., Yun, J., Lee, B. H., Kim, H. Y., & Yang, C. H. (2021). Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats. International Journal of Molecular Sciences, 22(14), 7519. https://doi.org/10.3390/ijms22147519

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Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats

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