Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies
Abstract
:1. Introduction
2. Results and Discussion
2.1. Synthesis of Star-Shaped Amphiphilic Block Copolymer
2.2. Cytotoxicity
2.3. Nifuratel Encapsulation
2.4. The Formation of Hydrogel Systems and Their Rheological Properties
3. Materials and Methods
3.1. Materials
3.2. Synthesis of (d,l-1,2-Isopropylidene glyceryl) Glycidyl Ether, IGG
3.3. Synthesis of Poly(furfuryl glycidyl ether), PFGE
3.4. Synthesis of Poly(furfuryl glycidyl ether)-b-Poly((d,l-1,2-isopropylidene glyceryl) glycidyl ether), PFGE-b-PIGG
3.5. Synthesis of Poly(furfuryl glycidyl ether)-b-Poly(glyceryl glycerol ether), PFGE-b-PGGE
3.6. Synthesis of Poly(2-acrylamidephenylboronic acid-ran-acrylamide), P(2-AAPBA-Ran-AM)
3.7. Solubilization of Nifuratel within Poly(furfuryl glycidyl ether)-b-Poly(glyceryl glycerol ether)
3.8. Drug Release
3.9. Instruments
3.9.1. H NMR and 1H DOSY NMR Spectroscopy
3.9.2. Gel Permeation Chromatography, GPC
3.9.3. Dynamic Light Scattering, DLS
3.9.4. Transmission Electron Microscopy, TEM
3.9.5. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, MALDI-TOF
3.9.6. Rheology
3.9.7. Cytotoxicity Assessment
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Polymer | DPn FGE (1H NMR) | DPn GGE (1H NMR) | Mn (1H NMR) | Mn (GPC) | Mw/Mn (GPC) |
---|---|---|---|---|---|
PFGE | 39 | - | 6000 | 4930 | 1.11 |
PFGE-b-PGGE | 39 | 426 | 61,000 | 57,800 | 1.28 |
Hydrogel | PFGE-b-PGGE (g) | P(2-AAPBA-b-AM) (g) | Weight Polymer Fraction (wt%) |
---|---|---|---|
H1 | 0.055 | 0.049 | 23 |
H2 | 0.055 | 0.025 | 18.5 |
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Ziemczonek, P.; Gosecka, M.; Gosecki, M.; Marcinkowska, M.; Janaszewska, A.; Klajnert-Maculewicz, B. Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies. Int. J. Mol. Sci. 2021, 22, 8386. https://doi.org/10.3390/ijms22168386
Ziemczonek P, Gosecka M, Gosecki M, Marcinkowska M, Janaszewska A, Klajnert-Maculewicz B. Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies. International Journal of Molecular Sciences. 2021; 22(16):8386. https://doi.org/10.3390/ijms22168386
Chicago/Turabian StyleZiemczonek, Piotr, Monika Gosecka, Mateusz Gosecki, Monika Marcinkowska, Anna Janaszewska, and Barbara Klajnert-Maculewicz. 2021. "Star-Shaped Poly(furfuryl glycidyl ether)-Block-Poly(glyceryl glycerol ether) as an Efficient Agent for the Enhancement of Nifuratel Solubility and for the Formation of Injectable and Self-Healable Hydrogel Platforms for the Gynaecological Therapies" International Journal of Molecular Sciences 22, no. 16: 8386. https://doi.org/10.3390/ijms22168386