Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

Jang, Hochung; Kim, Eun Hye; Chi, Sung-Gil; Kim, Sun Hwa; Yang, Yoosoo

doi:10.3390/ijms221810009

Open AccessReview

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

by

Hochung Jang

^1,2,†,

Eun Hye Kim

^1,3,†,

Sung-Gil Chi

³

,

Sun Hwa Kim

^1,* and

Yoosoo Yang

^1,2,*

¹

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Korea

²

Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea

³

Department of Life Sciences, Korea University, Seoul 02841, Korea

^*

Authors to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2021, 22(18), 10009; https://doi.org/10.3390/ijms221810009

Submission received: 26 August 2021 / Revised: 14 September 2021 / Accepted: 14 September 2021 / Published: 16 September 2021

(This article belongs to the Special Issue Nanomaterials in Cancer Diagnosis and Therapy)

Download

Browse Figures

Versions Notes

Abstract

A variety of innate immune cells such as macrophages, dendritic cells, myeloid-derived suppressor cells, natural killer cells, and neutrophils in the tumor microenvironments, contribute to tumor progression. However, while several recent reports have studied the use of immune checkpoint-based cancer immunotherapy, little work has focused on modulating the innate immune cells. This review focuses on the recent studies and challenges of using nanoparticles to target innate immune cells. In particular, we also examine the immunosuppressive properties of certain innate immune cells that limit clinical benefits. Understanding the cross-talk between tumors and innate immune cells could contribute to the development of strategies for manipulating the nanoparticles targeting tumor microenvironments.

Keywords: nanoparticles; innate immune cells; tumor microenvironment; cancer therapy

Share and Cite

MDPI and ACS Style

Jang, H.; Kim, E.H.; Chi, S.-G.; Kim, S.H.; Yang, Y. Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment. Int. J. Mol. Sci. 2021, 22, 10009. https://doi.org/10.3390/ijms221810009

AMA Style

Jang H, Kim EH, Chi S-G, Kim SH, Yang Y. Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment. International Journal of Molecular Sciences. 2021; 22(18):10009. https://doi.org/10.3390/ijms221810009

Chicago/Turabian Style

Jang, Hochung, Eun Hye Kim, Sung-Gil Chi, Sun Hwa Kim, and Yoosoo Yang. 2021. "Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment" International Journal of Molecular Sciences 22, no. 18: 10009. https://doi.org/10.3390/ijms221810009

APA Style

Jang, H., Kim, E. H., Chi, S.-G., Kim, S. H., & Yang, Y. (2021). Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment. International Journal of Molecular Sciences, 22(18), 10009. https://doi.org/10.3390/ijms221810009

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Nanoparticles Targeting Innate Immune Cells in Tumor Microenvironment

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI