Next Article in Journal
Local Interleukin-12 Treatment Enhances the Efficacy of Radiation Therapy by Overcoming Radiation-Induced Immune Suppression
Previous Article in Journal
Molecular Biomarkers for Pediatric Depressive Disorders: A Narrative Review
Previous Article in Special Issue
Inflammasome Signaling Regulates the Microbial–Neuroimmune Axis and Visceral Pain in Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 18
10.3390/ijms221810052
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders

by
Lucía N. Peralta-Marzal
1,*,
Naika Prince
1,
Djordje Bajic
2,3,
Léa Roussin
4,
Laurent Naudon
5,
Sylvie Rabot
4,
Johan Garssen
1,6,
Aletta D. Kraneveld
1 and
Paula Perez-Pardo
1,*
1
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands
2
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06511, USA
3
Microbial Sciences Institute, Yale University, West Haven, CT 06516, USA
4
Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
5
CNRS, Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France
6
Danone Nutricia Research, 3584 CT Utrecht, The Netherlands
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(18), 10052; https://doi.org/10.3390/ijms221810052
Submission received: 9 July 2021 / Revised: 13 September 2021 / Accepted: 14 September 2021 / Published: 17 September 2021
(This article belongs to the Special Issue Diet-Microbiota and Host Interactions in Intestinal Health and Inflammation)
Browse Figures
Versions Notes

Abstract

Autism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders characterised by behavioural impairment and deficiencies in social interaction and communication. A recent study estimated that 1 in 89 children have developed some form of ASD in European countries. Moreover, there is no specific treatment and since ASD is not a single clinical entity, the identification of molecular biomarkers for diagnosis remains challenging. Besides behavioural deficiencies, individuals with ASD often develop comorbid medical conditions including intestinal problems, which may reflect aberrations in the bidirectional communication between the brain and the gut. The impact of faecal microbial composition in brain development and behavioural functions has been repeatedly linked to ASD, as well as changes in the metabolic profile of individuals affected by ASD. Since metabolism is one of the major drivers of microbiome–host interactions, this review aims to report emerging literature showing shifts in gut microbiota metabolic function in ASD. Additionally, we discuss how these changes may be involved in and/or perpetuate ASD pathology. These valuable insights can help us to better comprehend ASD pathogenesis and may provide relevant biomarkers for improving diagnosis and identifying new therapeutic targets.
Keywords: autism spectrum disorders; microbiota–gut–brain axis; bacterial metabolites autism spectrum disorders; microbiota–gut–brain axis; bacterial metabolites

Share and Cite

MDPI and ACS Style

Peralta-Marzal, L.N.; Prince, N.; Bajic, D.; Roussin, L.; Naudon, L.; Rabot, S.; Garssen, J.; Kraneveld, A.D.; Perez-Pardo, P. The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders. Int. J. Mol. Sci. 2021, 22, 10052. https://doi.org/10.3390/ijms221810052

AMA Style

Peralta-Marzal LN, Prince N, Bajic D, Roussin L, Naudon L, Rabot S, Garssen J, Kraneveld AD, Perez-Pardo P. The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders. International Journal of Molecular Sciences. 2021; 22(18):10052. https://doi.org/10.3390/ijms221810052

Chicago/Turabian Style

Peralta-Marzal, Lucía N., Naika Prince, Djordje Bajic, Léa Roussin, Laurent Naudon, Sylvie Rabot, Johan Garssen, Aletta D. Kraneveld, and Paula Perez-Pardo. 2021. "The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders" International Journal of Molecular Sciences 22, no. 18: 10052. https://doi.org/10.3390/ijms221810052

APA Style

Peralta-Marzal, L. N., Prince, N., Bajic, D., Roussin, L., Naudon, L., Rabot, S., Garssen, J., Kraneveld, A. D., & Perez-Pardo, P. (2021). The Impact of Gut Microbiota-Derived Metabolites in Autism Spectrum Disorders. International Journal of Molecular Sciences, 22(18), 10052. https://doi.org/10.3390/ijms221810052

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop