Reactive Oxygen Species and Endothelial Ca2+ Signaling: Brothers in Arms or Partners in Crime?
Round 1
Reviewer 1 Report
The paper entitled 'Reactive oxygen species and endothelial Ca2+ signaling: Brothers in arms or partners in crime?' is a well-organized review.
Some minor issues should be addressed to improve the manuscript.
-Please revise the abstract. Line 23-24, please check the end of the sentence.
- There are some interesting papers that the authors should consider to add in their review.
Naziroğlu M, Lückhoff A. A calcium influx pathway regulated separately by oxidative stress and ADP-Ribose in TRPM2 channels: single channel events. Neurochem Res. 2008 Jul;33(7):1256-62. doi: 10.1007/s11064-007-9577-5. Epub 2008 Feb 8. PMID: 18259858. Nazıroğlu M. TRPM2 cation channels, oxidative stress and neurological diseases: where are we now? Neurochem Res. 2011 Mar;36(3):355-66. doi: 10.1007/s11064-010-0347-4. Epub 2010 Dec 8. PMID: 21140288. Pantke S, Fricke TC, Eberhardt MJ, Herzog C, Leffler A. Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms. Cell Calcium. 2021 Jun;96:102391. doi: 10.1016/j.ceca.2021.102391. Epub 2021 Mar 17. PMID: 33752082. Raghunatha P, Vosoughi A, Kauppinen TM, Jackson MF. Microglial NMDA receptors drive pro-inflammatory responses via PARP-1/TRMP2 signaling. Glia. 2020 Jul;68(7):1421-1434. doi: 10.1002/glia.23790. Epub 2020 Feb 8. PMID: 32036619. Stoica R, Rusu CM, Staicu CE, Burlacu AE, Radu M, Radu BM. Ca2+ homeostasis in brain microvascular endothelial cells. Int Rev Cell Mol Biol. 2021;362:55-110. doi: 10.1016/bs.ircmb.2021.01.001. Epub 2021 Feb 27. PMID: 34253298.
Author Response
Dear Referee #1,
We were happy to read your comments about our manuscript entitled: “Reactive oxygen species and endothelial Ca2+ signaling: Brothers in arms or partners in crime?” for publication as Review Article in International Journal of Molecular Sciences – Special Issue Calcium Signaling in Human Health and Diseases 3.0.
We truly believe that your comments did improve the quality of this manuscript and we are grateful for the attention you paid to our work. We amended the manuscript according to your indications and addressed all the criticisms you raised. More specifically:
- Please revise the abstract. Line 23-24, please check the end of the sentence.
Lines 23-24 were edited. Thank you for this suggestion!
- There are some interesting papers that the authors should consider to add in their review.
All the papers suggested by the Referee were added to the manuscript. We truly thank her/him for this suggestion.
We are grateful for your insightful revision and hope that you will not regard the manuscript worth being published on this Special Issue of the International Journal of Molecular Sciences.
With my kindest regards,
Francesco Moccia
Francesco Moccia, PhD
Laboratory of General Physiology,
Department of Biology and Biotechnology “L. Spallanzani”
University of Pavia,
Via Forlanini 6, 27100, Pavia, Italy.
Tel: 0039 0382 987614.
Fax: 0039 0382 987527.
E-mail: [email protected]
Reviewer 2 Report
The manuscript by Negri et al is a very complete and detailed review about reactive oxygen species, Ca2+ signals and vascular functions. The paper is well-structured, carefully and well written. The authors have clearly focused on the information published over the last years, which has indeed resulted in a timely review. The manuscript is written very well and I do not find any significant incorrectness. In my opinion, the manuscript should be published in the present form.
I just recommend the authors check the whole text for typographical mistakes. For instance, the title in line 32 should be in bold, as well as the title in line 77, etc.
Author Response
Dear Referee #2,
We were happy to read your comments about our manuscript entitled: “Reactive oxygen species and endothelial Ca2+ signaling: Brothers in arms or partners in crime?” for publication as Review Article in International Journal of Molecular Sciences – Special Issue Calcium Signaling in Human Health and Diseases 3.0.
We truly believe that your comments did improve the quality of this manuscript and we are grateful for the attention you paid to our work. We amended the manuscript according to your indications and addressed all the criticisms you raised.
More specifically:
- I just recommend the authors check the whole text for typographical mistakes. For instance, the title in line 32 should be in bold, as well as the title in line 77, etc.
We thank the Referee for this suggestion. The text has been thoughtfully checked to amend all the typos.
We are grateful for your insightful revision and hope that you will not regard the manuscript worth being published on this Special Issue of the International Journal of Molecular Sciences.
With my kindest regards,
Francesco Moccia
Francesco Moccia, PhD
Laboratory of General Physiology,
Department of Biology and Biotechnology “L. Spallanzani”
University of Pavia,
Via Forlanini 6, 27100, Pavia, Italy.
Tel: 0039 0382 987614.
Fax: 0039 0382 987527.
E-mail: [email protected]
