Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Toxicity Caused by Different Food-Derived Forms of Cadmium in Mice
Abstract
:1. Introduction
2. Results
2.1. Changes in Cadmium Content and Antioxidant Indexes in Livers and Kidneys
2.2. Changes in the Composition of the Intestinal Microbiota
2.3. Changes in Serum Metabolites
2.4. Correlation Analysis between Intestinal Microbiota and Serum Metabolites
3. Discussion
4. Materials and Methods
4.1. Preparation of Diverse Foodborne Forms of Cadmium
4.2. Preparation of L. plantarum CCFM8610
4.3. Animal Treatment
4.4. Determination of Cadmium Content
4.5. Analysis of Antioxidant Indexes in Livers and Kidneys
4.6. Analysis of Fecal Microbial Diversity
4.7. Metabolomics Analysis
4.8. Statistical Analysis
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Zhu, J.; Yu, L.; Shen, X.; Tian, F.; Zhao, J.; Zhang, H.; Chen, W.; Zhai, Q. Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Toxicity Caused by Different Food-Derived Forms of Cadmium in Mice. Int. J. Mol. Sci. 2021, 22, 11045. https://doi.org/10.3390/ijms222011045
Zhu J, Yu L, Shen X, Tian F, Zhao J, Zhang H, Chen W, Zhai Q. Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Toxicity Caused by Different Food-Derived Forms of Cadmium in Mice. International Journal of Molecular Sciences. 2021; 22(20):11045. https://doi.org/10.3390/ijms222011045
Chicago/Turabian StyleZhu, Jiamin, Leilei Yu, Xudan Shen, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, and Qixiao Zhai. 2021. "Protective Effects of Lactobacillus plantarum CCFM8610 against Acute Toxicity Caused by Different Food-Derived Forms of Cadmium in Mice" International Journal of Molecular Sciences 22, no. 20: 11045. https://doi.org/10.3390/ijms222011045