Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

de Sousa, Telma; Hébraud, Michel; Dapkevicius, Maria L. N. Enes; Maltez, Luís; Pereira, José Eduardo; Capita, Rosa; Alonso-Calleja, Carlos; Igrejas, Gilberto; Poeta, Patricia

doi:10.3390/ijms222312892

Open AccessReview

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

by

Telma de Sousa

^1,2,3,4

,

Michel Hébraud

^5,6

,

Maria L. N. Enes Dapkevicius

^7,8

,

Luís Maltez

^9,10

,

José Eduardo Pereira

^9,10,

Rosa Capita

^11,12

,

Carlos Alonso-Calleja

^11,12

,

Gilberto Igrejas

^1,3,4

and

Patricia Poeta

^2,4,*

¹

Department of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal

²

Microbiology and Antibiotic Resistance Team (MicroART), Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal

³

Functional Genomics and Proteomics Unit, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal

⁴

Associate Laboratory for Green Chemistry (LAQV), Chemistry Department, Faculty of Science and Technology, University Nova of Lisbon, 2829-516 Lisbon, Portugal

⁵

Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Metabolomic and Proteomic Exploration Facility (PFEM), 63122 Saint-Genès-Champanelle, France

⁶

Université Clermont Auvergne, INRAE, UMR Microbiologie Environnement Digestif Santé (MEDiS), 60122 Saint-Genès-Champanelle, France

⁷

Faculty of Agricultural and Environmental Sciences, University of the Azores, 9700-042 Angra do Heroísmo, Portugal

⁸

Institute of Agricultural and Environmental Research and Technology (IITAA), University of the Azores, 9700-042 Angra do Heroísmo, Portugal

⁹

Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal

¹⁰

Veterinary and Animal Research Centre, University of Trás-os-Montes and Alto Douro (UTAD), 5000-801 Vila Real, Portugal

¹¹

Department of Food Hygiene and Technology, Veterinary Faculty, University of León, E-24071 León, Spain

¹²

Institute of Food Science and Technology, University of León, E-24071 León, Spain

Show full affiliation list

Hide full affiliation list

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(23), 12892; https://doi.org/10.3390/ijms222312892

Submission received: 5 November 2021 / Revised: 26 November 2021 / Accepted: 27 November 2021 / Published: 29 November 2021

(This article belongs to the Section Molecular Microbiology)

Download

Browse Figures

Versions Notes

Abstract

In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas aeruginosa infections has gradually decreased. This pathogen can be observed in several clinical cases, such as pneumonia, urinary tract infections, sepsis, in immunocompromised hosts, such as neutropenic cancer, burns, and AIDS patients. Furthermore, Pseudomonas aeruginosa causes diseases in both livestock and pets. The highly flexible and versatile genome of P. aeruginosa allows it to have a high rate of pathogenicity. The numerous secreted virulence factors, resulting from its numerous secretion systems, the multi-resistance to different classes of antibiotics, and the ability to produce biofilms are pathogenicity factors that cause numerous problems in the fight against P. aeruginosa infections and that must be better understood for an effective treatment. Infections by P. aeruginosa represent, therefore, a major health problem and, as resistance genes can be disseminated between the microbiotas associated with humans, animals, and the environment, this issue needs be addressed on the basis of an One Health approach. This review intends to bring together and describe in detail the molecular and metabolic pathways in P. aeruginosa’s pathogenesis, to contribute for the development of a more targeted therapy against this pathogen.

Keywords: Pseudomonas aeruginosa; pathogenicity; multidrug-resistant; biofilm; virulence factors

Graphical Abstract

Share and Cite

MDPI and ACS Style

de Sousa, T.; Hébraud, M.; Dapkevicius, M.L.N.E.; Maltez, L.; Pereira, J.E.; Capita, R.; Alonso-Calleja, C.; Igrejas, G.; Poeta, P. Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa. Int. J. Mol. Sci. 2021, 22, 12892. https://doi.org/10.3390/ijms222312892

AMA Style

de Sousa T, Hébraud M, Dapkevicius MLNE, Maltez L, Pereira JE, Capita R, Alonso-Calleja C, Igrejas G, Poeta P. Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa. International Journal of Molecular Sciences. 2021; 22(23):12892. https://doi.org/10.3390/ijms222312892

Chicago/Turabian Style

de Sousa, Telma, Michel Hébraud, Maria L. N. Enes Dapkevicius, Luís Maltez, José Eduardo Pereira, Rosa Capita, Carlos Alonso-Calleja, Gilberto Igrejas, and Patricia Poeta. 2021. "Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa" International Journal of Molecular Sciences 22, no. 23: 12892. https://doi.org/10.3390/ijms222312892

APA Style

de Sousa, T., Hébraud, M., Dapkevicius, M. L. N. E., Maltez, L., Pereira, J. E., Capita, R., Alonso-Calleja, C., Igrejas, G., & Poeta, P. (2021). Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa. International Journal of Molecular Sciences, 22(23), 12892. https://doi.org/10.3390/ijms222312892

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Menu

Genomic and Metabolic Characteristics of the Pathogenicity in Pseudomonas aeruginosa

Abstract

Share and Cite

Article Metrics

Article Access Statistics

Further Information

Guidelines

MDPI Initiatives

Follow MDPI