Primaquine Inhibits the Endosomal Trafficking and Nuclear Localization of EGFR and Induces the Apoptosis of Breast Cancer Cells by Nuclear EGFR/Stat3-Mediated c-Myc Downregulation
Round 1
Reviewer 1 Report
Because both primaquine and chloroquine are studied in the manuscript, we recommend restoring the abstract with a description of the purpose and the results obtained for the 2 molecules known for their antimalarial action. We also recommend the inclusion in the Introduction section of some data on chloroquine from the literature and the motivation for inclusion in the study.
Finally, we recommend to the authors small revisions when editing the text, as follows:
- Description of all abbreviations and their subsequent use in the text:
- line 31 – abbreviations for HER2 – not described
- line 43 – Golgi/ER – not described
- line 43 – ER [estrogen receptor]
- line 71 – MTS
- line 72 – DMSO
- line 90 – SD
- line 96 – NOD-SCID
- all Latin expressions in italics
- line 20 – in vitro, in vivo;
- lines 242-243
- line 9 – Subtropical/Tropical Organism Gene Bank
- l 24 – nEGFR levels[,] and
- l 33-34 – is [an] epidermal growth factor receptor
- l 35-36 – same explanation – nuclear signaling (nuclear 35 EGFR, nEGFR)
- l 100 – Affects
- l 107 – was changed (see also line 108)
- l 137 – primaquine [lower case]
- l 144 – from merging EGFR…
- l 146 – lysed[,] and cytosolic
Author Response
Dear Reviewer
On behalf of my co-authors, we thank you for giving us an opportunity to revise our manuscript. We appreciate the reviewer for positive and constructive comments. We studied reviewer' comments carefully and made a revision. We tried our best to revise our manuscript according to the comments. Please find the revised version and the response to the reviewer, which we would like to submit for your kind consideration. We would like to express our great appreciation to you and the reviewer for the comments on our manuscript. Revised portion are marked in blue in the paper. We look forward to hear back from you.
Reviewer 2 Report
Great job
Author Response
Dear Reviewer
We appreciate the reviewer for positive comments. We would like to express our great appreciation to the reviewer for our manuscript.
